Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Ann Epidemiol. 2010 Jan;20(1):53-9. doi: 10.1016/j.annepidem.2009.10.001.
That circulating soluble form of intercellular adhesion molecule-1 (sICAM-1) is associated with an increased risk for coronary artery disease is well recognized. However, information is scant regarding the distribution and cardiovascular (CV) risk correlates of sICAM-1 in asymptomatic young adults.
Plasma sICAM-1 was measured in 1,184 black and white persons in the Bogalusa Heart Study cohort (70% white, 43% male), aged 24 to 44 years. CV risk was assessed in terms of CV risk factors, status of parental CV disease, and composite carotid intima-media thickness (IMT).
sICAM-1 levels displayed race difference (whites > blacks, p<0.0001), but no sex difference. In multivariate analysis including age, race, sex, smoking status, waist circumference, mean arterial pressure, low- and high-density lipoprotein (LDL and HDL) cholesterols, triglycerides, insulin resistance index, C-reactive protein (CRP), and adiponectin, the significant predictors of sICAM-1, in order of entry, were race (white > black), smoking, CRP, and waist circumference. Furthermore, there was a smoking by waist circumference interaction in that smoking attenuated the magnitude of correlation between waist circumference and sICAM-1. Levels of sICAM-1 adjusted for age, race, sex, and smoking increased with number of metabolic syndrome components (p for trend<0.01); positive family history of CV disease (p<0.05); and increased in composite carotid IMT specific for age, race, and sex (p for trend<0.05).
These findings underscore the potential value of plasma sICAM-1 as an additional biomarker for CV risk among asymptomatic young adults.
众所周知，循环可溶性细胞间黏附分子-1（sICAM-1）与冠状动脉疾病风险增加有关。然而，关于无症状年轻成年人中 sICAM-1 的分布和心血管（CV）风险相关性的信息很少。
在博加卢萨心脏研究队列（70%白人，43%男性）的 1184 名黑人和白人中测量了血浆 sICAM-1，年龄在 24 至 44 岁之间。根据 CV 危险因素、父母 CV 疾病状况以及复合颈动脉内膜中层厚度（IMT）评估 CV 风险。
sICAM-1 水平存在种族差异（白人>黑人，p<0.0001），但无性别差异。在包括年龄、种族、性别、吸烟状况、腰围、平均动脉压、低和高密度脂蛋白（LDL 和 HDL）胆固醇、甘油三酯、胰岛素抵抗指数、C-反应蛋白（CRP）和脂联素在内的多变量分析中，sICAM-1 的显著预测因素按进入顺序依次为种族（白人>黑人）、吸烟、CRP 和腰围。此外，腰围和吸烟之间存在交互作用，即吸烟减弱了腰围与 sICAM-1 之间相关性的程度。经年龄、种族、性别和吸烟调整后的 sICAM-1 水平随着代谢综合征成分数量的增加而增加（趋势 p<0.01）；有 CV 疾病家族史（p<0.05）；以及与年龄、种族和性别相关的复合颈动脉 IMT 增加（趋势 p<0.05）。
这些发现强调了血浆 sICAM-1 作为无症状年轻成年人心血管风险的附加生物标志物的潜在价值。
