足细胞与肾小球随增龄变化的功能。
Podocytes and glomerular function with aging.
机构信息
Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5676, USA.
出版信息
Semin Nephrol. 2009 Nov;29(6):587-93. doi: 10.1016/j.semnephrol.2009.07.012.
Abstract
Kidney function declines with age in association with the development of age-associated glomerulosclerosis. The well-established structural and functional changes with age are reviewed briefly. The modification of aging pathology by calorie restriction is discussed. The role of the podocyte as a critical cell in the aging process is considered, using animal models and human biopsy material. Newer data on changes in gene expression and possible changes in biology in the glomerulus are discussed. There is speculation on the implications of this change in biology for human disease and progression.
摘要
肾功能随年龄增长而下降，与年龄相关的肾小球硬化症的发展有关。简要回顾了与年龄相关的已确立的结构和功能变化。讨论了热量限制对衰老病理的修饰作用。使用动物模型和人类活检材料，考虑了足细胞作为衰老过程中关键细胞的作用。讨论了肾小球中基因表达的变化和生物学变化的新数据。推测这种生物学变化对人类疾病和进展的影响。
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