足细胞与肾小球随增龄变化的功能。
Podocytes and glomerular function with aging.
机构信息
Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-5676, USA.
出版信息
Semin Nephrol. 2009 Nov;29(6):587-93. doi: 10.1016/j.semnephrol.2009.07.012.
Abstract
Kidney function declines with age in association with the development of age-associated glomerulosclerosis. The well-established structural and functional changes with age are reviewed briefly. The modification of aging pathology by calorie restriction is discussed. The role of the podocyte as a critical cell in the aging process is considered, using animal models and human biopsy material. Newer data on changes in gene expression and possible changes in biology in the glomerulus are discussed. There is speculation on the implications of this change in biology for human disease and progression.
摘要
肾功能随年龄增长而下降，与年龄相关的肾小球硬化症的发展有关。简要回顾了与年龄相关的已确立的结构和功能变化。讨论了热量限制对衰老病理的修饰作用。使用动物模型和人类活检材料，考虑了足细胞作为衰老过程中关键细胞的作用。讨论了肾小球中基因表达的变化和生物学变化的新数据。推测这种生物学变化对人类疾病和进展的影响。
相似文献
1
Podocytes and glomerular function with aging.
Semin Nephrol. 2009 Nov;29(6):587-93. doi: 10.1016/j.semnephrol.2009.07.012.
2
Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction.
J Am Soc Nephrol. 2005 Oct;16(10):2953-66. doi: 10.1681/ASN.2005050488. Epub 2005 Aug 24.
3
Aging in the glomerulus.
J Gerontol A Biol Sci Med Sci. 2012 Dec;67(12):1358-64. doi: 10.1093/gerona/gls157. Epub 2012 Jul 25.
4
Podocyte biology in segmental sclerosis and progressive glomerular injury.
Adv Chronic Kidney Dis. 2012 Mar;19(2):76-83. doi: 10.1053/j.ackd.2012.02.018.
5
Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition.
Hypertension. 2004 Dec;44(6):974-81. doi: 10.1161/01.HYP.0000149249.09147.b4. Epub 2004 Nov 15.
6
Growth-dependent podocyte failure causes glomerulosclerosis.
J Am Soc Nephrol. 2012 Aug;23(8):1351-63. doi: 10.1681/ASN.2012030271. Epub 2012 Jul 5.
7
Glomerular scarring: can we delay or even reverse glomerulosclerosis by RAAS inhibition?
Nephrol Dial Transplant. 2010 Jul;25(7):2101-3. doi: 10.1093/ndt/gfq182. Epub 2010 Apr 12.
8
A high-powered view of the filtration barrier.
J Am Soc Nephrol. 2010 Nov;21(11):1835-41. doi: 10.1681/ASN.2010040378. Epub 2010 Jun 24.
9
Pathophysiology of focal segmental glomerulosclerosis.
Pediatr Nephrol. 2007 Mar;22(3):350-4. doi: 10.1007/s00467-006-0357-2. Epub 2007 Jan 10.
10
Clinical significance of fibroblast-specific protein-1 expression on podocytes in patients with focal segmental glomerulosclerosis.
Nephron Clin Pract. 2012;120(1):c1-7. doi: 10.1159/000334184. Epub 2011 Nov 23.
引用本文的文献
1
The Life of a Kidney Podocyte.
Acta Physiol (Oxf). 2025 Aug;241(8):e70081. doi: 10.1111/apha.70081.
2
Functional Microendoscopy Reveals Calcium Responses of Single Cells in Tracheal Tuft Cells and Kidney Podocytes.
Small. 2025 May;21(21):e2411341. doi: 10.1002/smll.202411341. Epub 2025 Apr 1.
3
Oxidative stress and senescence in aging kidneys: the protective role of SIRT1.
EXCLI J. 2024 Aug 27;23:1030-1067. doi: 10.17179/excli2024-7519. eCollection 2024.
4
Podocyte-specific proteins in urinary extracellular vesicles of patients with IgA nephropathy: Vasorin and ceruloplasmin.
Bioimpacts. 2024;14(3):29981. doi: 10.34172/bi.2023.29981. Epub 2023 Oct 31.
5
Podocyte injury at young age causes premature senescence and worsens glomerular aging.
Am J Physiol Renal Physiol. 2024 Jan 1;326(1):F120-F134. doi: 10.1152/ajprenal.00261.2023. Epub 2023 Oct 19.
6
Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span.
Aging (Albany NY). 2023 Jul 23;15(14):6658-6689. doi: 10.18632/aging.204897.
7
Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.
Geroscience. 2023 Aug;45(4):2245-2255. doi: 10.1007/s11357-023-00754-0. Epub 2023 Feb 25.
8
The Effects of TRPC6 Knockout in Animal Models of Kidney Disease.
Biomolecules. 2022 Nov 18;12(11):1710. doi: 10.3390/biom12111710.
9
Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats.
Cells. 2021 Apr 9;10(4):856. doi: 10.3390/cells10040856.
10
Global transcriptomic changes occur in aged mouse podocytes.
Kidney Int. 2020 Nov;98(5):1160-1173. doi: 10.1016/j.kint.2020.05.052. Epub 2020 Jun 25.
本文引用的文献
1
Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan.
Am J Pathol. 2008 Aug;173(2):327-36. doi: 10.2353/ajpath.2008.080152. Epub 2008 Jul 3.
2
Drosophila aging 2006/2007.
Exp Gerontol. 2008 Jan;43(1):5-10. doi: 10.1016/j.exger.2007.10.008. Epub 2007 Dec 3.
3
Nephrin--a unique structural and signaling protein of the kidney filter.
Trends Mol Med. 2007 Sep;13(9):396-403. doi: 10.1016/j.molmed.2007.06.006. Epub 2007 Sep 4.
4
Reproduction and longevity: secrets revealed by C. elegans.
Trends Cell Biol. 2007 Feb;17(2):65-71. doi: 10.1016/j.tcb.2006.12.004. Epub 2006 Dec 21.
5
New findings in transgenic, gene knockout and mutant mice.
Exp Gerontol. 2006 Dec;41(12):1217-9. doi: 10.1016/j.exger.2006.09.001. Epub 2006 Oct 17.
6
Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet.
J Am Soc Nephrol. 2006 May;17(5):1382-7. doi: 10.1681/ASN.2005111239. Epub 2006 Apr 5.
7
Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction.
J Am Soc Nephrol. 2005 Oct;16(10):2953-66. doi: 10.1681/ASN.2005050488. Epub 2005 Aug 24.
8
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene.
J Am Soc Nephrol. 2005 Oct;16(10):2941-52. doi: 10.1681/ASN.2005010055. Epub 2005 Aug 17.
9
The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family.
J Am Soc Nephrol. 2004 Oct;15(10):2514-27. doi: 10.1097/01.ASN.0000141462.00630.76.
10
Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome.
Kidney Int. 2004 Aug;66(2):564-70. doi: 10.1111/j.1523-1755.2004.00775.x.
Zotero 插件