丙型肝炎与干扰素系统的逃逸：一种 PKR 范例。
Hepatitis C and evasion of the interferon system: a PKR paradigm.
机构信息
Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, CSIC, Madrid, Spain.
出版信息
Cell Host Microbe. 2009 Dec 17;6(6):495-7. doi: 10.1016/j.chom.2009.11.009.
PMID:20006836
Abstract
Hepatitis C virus (HCV) is resistant to the antiviral cytokine type I interferon, representing a major clinical problem. Garaigorta and Chisari (2009) reveal that HCV uses the activation of the ds-RNA-dependent protein kinase R, which phosphorylates and inhibits the translation initiation factor eIF-2 alpha, to block translation of interferon-stimulated genes.
摘要
丙型肝炎病毒（HCV）对抗病毒细胞因子 I 型干扰素具有抗性，这是一个主要的临床问题。Garaigorta 和 Chisari（2009）揭示了 HCV 利用双链 RNA 依赖的蛋白激酶 R 的激活，磷酸化并抑制翻译起始因子 eIF-2α，从而阻断干扰素刺激基因的翻译。
Zotero 插件