Individual differences in activity predict locomotor activity and conditioned place preference to amphetamine in both adolescent and adult rats.

Individual and developmental differences in novelty seeking have been implicated in differential sensitivity to psychostimulants in rodents, but findings are mixed. The extent to which age differences in activity in a novel arena depended on test duration was examined by comparing adolescent and adult rats after 5 and after 60 min of testing (session 1). Rats were tested again after amphetamine or saline administration 24h later (session 2) to examine whether activity in a novel arena predicts sensitivity to locomotor-activating effects of amphetamine. Data from two experiments were used to examine consistency of the findings. Only activity in 60 min sessions produced a consistent age difference (adolescent<adult) and predicted activity after amphetamine in session 2. Session 1 activity also predicted saline activity in session 2, indicating that individual differences in activity is a stable trait. A third data set was used to determine whether general (saline) and amphetamine-induced activity predicted magnitude of conditioned place preference (CPP) in late-adolescent and adult rats. Age was not a significant predictor, but CPP was positively associated with amphetamine activity and negatively associated with saline activity. Thus, in contrast to enhanced psychostimulant sensitivity in high novelty-seekers, rats higher in general activity are less sensitive to amphetamine conditioned place preference.