Dipartimento di Ingegneria Chimica, Università di Napoli Federico II, p.le V. Tecchio 80, 80125 Napoli, Italy.
J Hazard Mater. 2010 Apr 15;176(1-3):575-8. doi: 10.1016/j.jhazmat.2009.11.067. Epub 2009 Nov 18.
The knowledge of the substances which form when a molecule undergoes chemical reactions under unusual conditions is required by European legislation to evaluate the risks associated with an industrial chemical process. A thermal decomposition is often the result of a loss of control of the process which leads to the formation of many substances in some cases not easily predictable. The evaluation of the change of an overall toxicity passing from the parent compound to the mixture of its thermal decomposition products has been already proposed as a practical approach to this problem when preliminary indications about the temperature range in which the molecule decomposes are available. A new procedure is proposed in this work for the obtainment of the mixtures of thermal decomposition products also when there is no previous information about the thermal behaviour of investigated molecules. A scanning calorimetric run that is aimed to identify the onset temperature of the decomposition process is coupled to an isoperibolic one in order to obtain and collect the products. An algal strain is adopted for toxicological assessments of chemical compounds and mixtures. An extension of toxicological investigations to human cells is also attempted.
欧洲法规要求了解分子在异常条件下发生化学反应时形成的物质，以评估与工业化学过程相关的风险。热分解通常是由于过程失去控制导致形成许多物质的结果，在某些情况下，这些物质不容易预测。当有初步迹象表明分子分解的温度范围时，已经提出了从母体化合物到其热分解产物混合物的整体毒性变化的评估作为解决此问题的一种实用方法。在这项工作中，提出了一种新的方法来获得热分解产物的混合物，即使没有关于被研究分子的热行为的先前信息。为了获得和收集产物，将旨在确定分解过程起始温度的扫描量热法运行与等压运行相结合。采用藻类菌株进行化合物和混合物的毒理学评估。还试图将毒理学研究扩展到人类细胞。
