Nozaki S, Garg A, Vega G L, Grundy S M
Veterans Administration Medical Center, Dallas, TX.
Am J Clin Nutr. 1991 Mar;53(3):638-42. doi: 10.1093/ajcn/53.3.638.
The hypotriglyceridemic action of omega-3 (n-3) fatty acids is attributed primarily to reduction in hepatic triglyceride synthesis and reduced secretion of very-low-density lipoproteins (VLDLs). However, increased catabolism of triglyceride-rich lipoproteins was reported and could be due to increased availability of peripheral lipoprotein lipase (LPL) or hepatic lipase (HL). In this study plasma lipoproteins and postheparin activities of LPL and HL were determined in 12 patients with primary hypertriglyceridemia before and during isocaloric substitution of omega-3 fatty acids (10 g/d) for 4 wk. Omega-3 polyunsaturates resulted in 53% and 61% reductions in plasma triglyceride and VLDL-cholesterol concentrations, respectively (P less than 0.0001). However, low-density-lipoprotein (LDL)-cholesterol concentrations increased by 26% (P less than 0.001). Activities of postheparin LPL and HL essentially remained the same. Thus, in patients with primary hypertriglyceridemia, reduction in plasma triglyceride concentrations and increase in LDL-cholesterol concentrations mediated by omega-3 polyunsaturates seem to occur without an increase in LPL or HL activities.
ω-3（n-3）脂肪酸的降甘油三酯作用主要归因于肝脏甘油三酯合成的减少以及极低密度脂蛋白（VLDL）分泌的降低。然而，有报道称富含甘油三酯的脂蛋白分解代谢增加，这可能是由于外周脂蛋白脂肪酶（LPL）或肝脂肪酶（HL）的可用性增加所致。在本研究中，对12例原发性高甘油三酯血症患者在以ω-3脂肪酸（10 g/天）进行等热量替代4周之前和期间测定了血浆脂蛋白以及LPL和HL的肝素后活性。ω-3多不饱和脂肪酸分别使血浆甘油三酯和VLDL胆固醇浓度降低了53%和61%（P<0.0001）。然而，低密度脂蛋白（LDL）胆固醇浓度增加了26%（P<0.001）。肝素后LPL和HL的活性基本保持不变。因此，在原发性高甘油三酯血症患者中，ω-3多不饱和脂肪酸介导的血浆甘油三酯浓度降低和LDL胆固醇浓度升高似乎是在LPL或HL活性未增加的情况下发生的。
