Jindahra Panitha, Hedges Thomas R, Mendoza-Santiesteban Carlos E, Plant Gordon T
The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Curr Opin Neurol. 2010 Feb;23(1):16-23. doi: 10.1097/WCO.0b013e328334e99b.
This review summarizes the mechanisms and recent developments of optical coherence tomography and its practical uses in neurology. The application of optical coherence tomography imaging of the retina in multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease are reviewed.
Thinning of the peripapillary retinal nerve fibre layer has been detected in patients with optic neuritis, multiple sclerosis, neuromyelitis optica, Alzheimer disease, and Parkinson disease. However, the patterns of change differ in some aspects.
The findings indicate loss of retinal ganglion cells and may reflect degenerative change in the brain in these conditions. The retinal nerve fibre layer thickness may be used as a biological marker and may help to distinguish between optic neuritis associated with multiple sclerosis and optic neuritis in neuromyelitis optica.
本综述总结了光学相干断层扫描的机制、近期进展及其在神经病学中的实际应用。对视网膜光学相干断层扫描成像在多发性硬化症、视神经脊髓炎、阿尔茨海默病和帕金森病中的应用进行了综述。
在视神经炎、多发性硬化症、视神经脊髓炎、阿尔茨海默病和帕金森病患者中均检测到视乳头周围视网膜神经纤维层变薄。然而，在某些方面变化模式有所不同。
这些发现表明视网膜神经节细胞丢失，可能反映了这些情况下大脑的退行性变化。视网膜神经纤维层厚度可作为一种生物学标志物，可能有助于区分多发性硬化症相关的视神经炎和视神经脊髓炎中的视神经炎。
