紧密连接蛋白在炎症中的内吞作用与再循环
Endocytosis and recycling of tight junction proteins in inflammation.
作者信息
Utech Markus, Mennigen Rudolf, Bruewer Matthias
机构信息
Department of General and Visceral Surgery, University Hospital Muenster, 48149 Muenster, Germany.
出版信息
J Biomed Biotechnol. 2010;2010:484987. doi: 10.1155/2010/484987.
Abstract
A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium. This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised under inflammatory conditions. In intestinal epithelial cells, proinflammatory cytokines, for example, interferon-gamma (IFN-gamma), induce internalization of TJ proteins by endocytosis. Endocytosed TJ proteins are passed into early and recycling endosomes, suggesting the involvement of recycling of internalized TJ proteins. This review summarizes mechanisms by which TJ proteins under inflammatory conditions are internalized in intestinal epithelial cells and point out comparable mechanism in nonintestinal epithelial cells.
摘要
上皮内衬的一项关键功能是形成一道屏障，将管腔内容物与下方的间质分隔开来。这种屏障功能主要由由紧密连接（TJ）和黏附连接（AJ）组成的顶端连接复合体（AJC）调节，并且在炎症条件下会受到损害。例如，在肠道上皮细胞中，促炎细胞因子，如干扰素-γ（IFN-γ），通过内吞作用诱导TJ蛋白内化。内吞的TJ蛋白进入早期和再循环内体，表示内化的TJ蛋白参与了再循环。本综述总结了炎症条件下TJ蛋白在肠道上皮细胞中内化的机制，并指出了非肠道上皮细胞中的类似机制。
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