IL-17RC：IL-17 信号通路的伙伴及其它作用。
IL-17RC: a partner in IL-17 signaling and beyond.
机构信息
Department of Oral Biology, State University of New York, Buffalo, 14214, USA.
出版信息
Semin Immunopathol. 2010 Mar;32(1):33-42. doi: 10.1007/s00281-009-0185-0. Epub 2009 Dec 13.
Abstract
The interleukin (IL)-17 cytokine family members IL-17A and IL-17F mediate inflammatory activities via the IL-17 receptor (IL-17R) complex, comprised of the IL-17RA and IL-17RC subunits. Proper regulation of the IL-17 signaling axis results in effective host defense against extracellular pathogens, while aberrant signaling can drive autoimmune pathology. Elucidating the molecular mechanisms underlying IL-17 signal transduction can yield an enhanced understanding of inflammatory immune processes and also create an avenue for therapeutic intervention in the treatment of IL-17-dependent diseases. To date, the fundamental signaling mechanisms used by the IL-17R complex are still incompletely defined. While current structure-function studies have primarily focused on the IL-17RA subunit, recent research indicates that the IL-17RC subunit plays a key role in modulating IL-17 responses. This review will examine what is known regarding IL-17RC function and provide a framework for future work on this subunit and its impact on human health.
摘要
白细胞介素 (IL)-17 细胞因子家族成员 IL-17A 和 IL-17F 通过包含 IL-17RA 和 IL-17RC 亚基的 IL-17 受体 (IL-17R) 复合物介导炎症活性。IL-17 信号轴的适当调节可导致宿主有效抵抗细胞外病原体，而异常信号可驱动自身免疫病理学。阐明 IL-17 信号转导的分子机制可以增强对炎症免疫过程的理解，也为治疗依赖 IL-17 的疾病的治疗干预创造途径。迄今为止，IL-17R 复合物使用的基本信号机制仍未完全定义。虽然当前的结构-功能研究主要集中在 IL-17RA 亚基上，但最近的研究表明，IL-17RC 亚基在调节 IL-17 反应中起着关键作用。这篇综述将检查关于 IL-17RC 功能的已知内容，并为该亚基及其对人类健康的影响的未来工作提供框架。
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