生物技术管道中的 Wnt 调节剂。
Wnt modulators in the biotech pipeline.
机构信息
OsteoGeneX Inc., Kansas City, Kansas 66160, USA.
出版信息
Dev Dyn. 2010 Jan;239(1):102-14. doi: 10.1002/dvdy.22181.
Abstract
The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.
摘要
本篇综述旨在深入了解 LRP 共受体介导的 Wnt 信号通路。采用蛋白质组学方法，我们还将 LRP 受体家族细分为六个亚家族，包含 12 个家族成员。本综述讨论了含有半胱氨酸结蛋白基序的蛋白（即 Sclerostin、Dan、Sostdc1、Vwf、Norrin、Pdgf、Mucin），并探讨了该基序如何通过与 LRP 的相互作用来介导 Wnt 信号转导。
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本文引用的文献
1
Role of Wnt/β-catenin signaling in liver metabolism and cancer.
Int J Biochem Cell Biol. 2011 Jul;43(7):1021-9. doi: 10.1016/j.biocel.2009.09.001. Epub 2009 Sep 9.
2
Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer.
Clin Cancer Res. 2009 Sep 15;15(18):5784-93. doi: 10.1158/1078-0432.CCR-09-0814. Epub 2009 Sep 8.
3
Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.
J Cell Physiol. 2009 Dec;221(3):658-67. doi: 10.1002/jcp.21902.
4
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.
J Clin Invest. 2009 Sep;119(9):2538-49. doi: 10.1172/JCI38079. Epub 2009 Aug 17.
5
Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK.
J Mol Biol. 2009 Oct 16;393(1):1-9. doi: 10.1016/j.jmb.2009.07.091. Epub 2009 Aug 4.
6
Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.
Gastroenterology. 2009 Jul;137(1):242-52, 252.e1-6. doi: 10.1053/j.gastro.2009.02.003.
7
Wnt antagonist gene polymorphisms and renal cancer.
Cancer. 2009 Oct 1;115(19):4488-503. doi: 10.1002/cncr.24491.
8
PPARgamma and Wnt/beta-Catenin pathway in human breast cancer: expression pattern, molecular interaction and clinical/prognostic correlations.
J Cancer Res Clin Oncol. 2009 Nov;135(11):1551-9. doi: 10.1007/s00432-009-0602-8. Epub 2009 Jun 3.
9
WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics.
Cell Res. 2009 Jun;19(6):683-97. doi: 10.1038/cr.2009.43.
10
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