系统性红斑狼疮患者行腹膜透析与血液透析的临床疗效比较。
Peritoneal dialysis and hemodialysis in systemic lupus erythematosus patients: comparison of clinical outcomes.
机构信息
Department of Nephrology, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan, Taiwan, ROC.
出版信息
Kidney Blood Press Res. 2009;32(6):451-6. doi: 10.1159/000266480. Epub 2009 Dec 17.
BACKGROUND
This study compared peritoneal dialysis (PD) and hemodialysis (HD) outcomes between female systemic lupus erythematosus (SLE) patients with end-stage renal disease (ESRD) due to lupus nephropathy.
METHODS
22 female SLE patients undergoing PD were compared with 14 female SLE patients receiving HD. Clinical outcomes and infective complications were reviewed.
RESULTS
The overall mortality rate was much higher in the PD group (6/22) than in the HD group (1/14) (p = 0.027). PD patients had higher C-reactive protein level (37.1 +/- 41.4 vs. 6.7 +/- 9.5 mg/l, p = 0.037) and numbers of infectious episode (PD vs. HD: 1 episode per 33.16 patient-months vs. 1 episode per 118.26 patient-months, respectively, p = 0.046). Before the end of the observation period, HD patients had higher serum albumin (3.8 +/- 0.2 vs. 3.3 +/- 0.6 g/dl, p = 0.01).
CONCLUSIONS
In female SLE patients with ESRD due to lupus nephropathy, clinical outcomes are better after undergoing HD than after undergoing PD.
背景
本研究比较了狼疮性肾炎导致终末期肾病的女性系统性红斑狼疮（SLE）患者行腹膜透析（PD）和血液透析（HD）的结局。
方法
将 22 名接受 PD 的女性 SLE 患者与 14 名接受 HD 的女性 SLE 患者进行比较。回顾了临床结局和感染性并发症。
结果
PD 组（6/22）的总死亡率明显高于 HD 组（1/14）（p = 0.027）。PD 患者的 C 反应蛋白水平（37.1 +/- 41.4 与 6.7 +/- 9.5 mg/l，p = 0.037）和感染次数（PD 与 HD：每 33.16 个患者月 1 次与每 118.26 个患者月 1 次，p = 0.046）更高。在观察期末前，HD 患者的血清白蛋白更高（3.8 +/- 0.2 与 3.3 +/- 0.6 g/dl，p = 0.01）。
结论
在狼疮性肾炎导致终末期肾病的女性 SLE 患者中，HD 后的临床结局优于 PD。
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