Breast Cancer Res. 2009;11(6):111. doi: 10.1186/bcr2451. Epub 2009 Nov 26.
Poly(ADP-ribose) polymerase (PARP) inhibitors have been explored as therapeutic agents for the treatment of hereditary breast and ovarian cancers harboring mutations in BRCA1 or BRCA2. In a new study, Inbar-Rozensal and colleagues show that phenanthridine-derived PARP inhibitors promote cell cycle arrest and cell death in breast cancer cells lacking BRCA1 and BRCA2 mutations and prevent the growth of tumors from xenografts of these cells in immunocompromised mice. These results suggest a potential broader utility of PARP-1 inhibitors in the treatment of breast cancer, although further mechanistic studies are needed.
聚(ADP-核糖)聚合酶(PARP)抑制剂已被探索用于治疗携带 BRCA1 或 BRCA2 突变的遗传性乳腺癌和卵巢癌。在一项新的研究中,Inbar-Rozensal 及其同事表明,菲啶衍生的 PARP 抑制剂可促进缺乏 BRCA1 和 BRCA2 突变的乳腺癌细胞的细胞周期停滞和细胞死亡,并防止这些细胞的异种移植物在免疫功能低下的小鼠中生长肿瘤。这些结果表明 PARP-1 抑制剂在乳腺癌治疗中有潜在的更广泛的应用,尽管需要进一步的机制研究。