Baxter Bioscience, Biomedical Research Centre, A-2304, Uferstrasse 15, Orth/Donau, Austria.
Vaccine. 2010 Feb 17;28(7):1778-85. doi: 10.1016/j.vaccine.2009.12.008. Epub 2009 Dec 16.
Recent findings indicate that seasonal influenza vaccination or infection of healthy humans may contribute to heterosubtypic immunity against new influenza A subtypes, such as H5N1. Here, we investigated whether seasonal influenza vaccination in a mouse model could induce any immunity against the H5N1 subtype. It could be demonstrated that, largely due to the H1N1 component strain A/NewCaledonia/20/99, parenteral immunization of mice with a trivalent seasonal influenza vaccine elicited heterosubtype H5-reactive antibodies able to confer partial protection against H5N1 influenza virus infection. Furthermore, the trivalent seasonal influenza vaccine was found to be compatible with a whole virus H5N1 vaccine in a heterologous prime-boost immunization regimen, achieving superior efficacy compared to a single immunization with an equivalent low-dose of the H5N1 vaccine.
最近的研究结果表明,季节性流感疫苗接种或健康人群的感染可能有助于对新的甲型流感亚型(如 H5N1)产生异亚型免疫。在这里,我们研究了在小鼠模型中季节性流感疫苗接种是否可以诱导对 H5N1 亚型的任何免疫。可以证明,由于 H1N1 成分株 A/NewCaledonia/20/99,通过三价季节性流感疫苗对小鼠进行的肠胃外免疫引发了能够提供针对 H5N1 流感病毒感染的部分保护的异亚型 H5 反应性抗体。此外,三价季节性流感疫苗在异源初免-加强免疫方案中与全病毒 H5N1 疫苗相容,与单次接种相同低剂量 H5N1 疫苗相比,实现了更高的疗效。