[儿童弥漫性脑桥内生型胶质瘤：当前治疗方法与未来方向]

[Diffuse intrinsic brain stem glioma in children: current treatment and future directions].

作者信息

Leblond P, Vinchon M, Bernier-Chastagner V, Chastagner P

机构信息

Unité d'oncologie pédiatrique, centre Oscar-Lambret, 59020 Lille cedex, France.

出版信息

Arch Pediatr. 2010 Feb;17(2):159-65. doi: 10.1016/j.arcped.2009.11.016. Epub 2009 Dec 16.

DOI:10.1016/j.arcped.2009.11.016

PMID:20018494

Abstract

Despite the numerous clinical trials undertaken, the prognosis of children with diffuse brain stem glioma remains very poor. This review examines the different strategies for the treatment of malignant brain stem glioma such as radiation therapy, concurrent radiochemotherapy, and classical cytotoxic drugs, with a particular focus on the novel targeted and antiangiogenic drugs recently introduced in pediatric oncology. The strategy using integrin inhibitors is discussed.

摘要

尽管进行了大量临床试验，但弥漫性脑干胶质瘤患儿的预后仍然很差。本综述探讨了治疗恶性脑干胶质瘤的不同策略，如放射治疗、同步放化疗和传统细胞毒性药物，特别关注儿科肿瘤学中最近引入的新型靶向药物和抗血管生成药物。还讨论了使用整合素抑制剂的策略。