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吸入甲醛对大鼠小脑发育期氧化应激系统的影响。

The effects of inhaled formaldehyde on oxidant and antioxidant systems of rat cerebellum during the postnatal development process.

机构信息

Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, Turkey.

出版信息

Toxicol Mech Methods. 2008 Jan;18(7):569-74. doi: 10.1080/15376510701555288.

Abstract

ABSTRACT The aim of this study was to examine the effects of formaldehyde (FA) inhalation during the early postnatal period on some oxidant and antioxidant systems of rat cerebellum in the developmental process and to determine whether the changes were reversible or not. After birth, 0 (control), 6, or 12 ppm FA5 was given to the neonatal rats throughout 30 days. This was done by placing them for 6 h/day and 5 day/week in a glass chamber containing FA vapor. After cessation of the FA exposing process, seven rats from each group were decapitated on postnatal day (PND) 30 and the remaining seven rats were decapitated on the PND 90, and all cerebellums were removed immediately. On samples, levels of malondialdehyde (MDA) and nitric oxide (NO) and activities of total superoxide dismutase (t-SOD) and glutathione peroxidase (GSH-px) enzymes were measured. We found that activity of GSH-Px and levels of MDA and NO increased; on the other hand, activity of t-SOD decreased significantly in the rats treated with FA compared to control rats at PND 30. In general, the findings at PND 90 were similar to PND 30. Additionally, we observed that the 12-ppm FA-inhaling rats were more affected than the 6-ppm FA-inhaling rats, especially at PND 30. As a result, the present findings suggest that inhalation of FA during the early postnatal period affects the oxidant and antioxidant systems and increases some free radicals in the rat cerebellum in a dose-related manner. We think that these changes were carried on for a long time or may cause irreversible toxicity and oxidative damage.

摘要

摘要 本研究旨在探讨新生期吸入甲醛(FA)对大鼠小脑发育过程中某些氧化应激和抗氧化系统的影响,并确定这些变化是否具有可逆性。新生大鼠在出生后 30 天内通过每天 6 小时和每周 5 天暴露于含 FA 蒸气的玻璃室中,接受 0(对照)、6 或 12ppm FA5。暴露过程停止后,每组有 7 只大鼠于生后第 30 天断头,其余 7 只大鼠于第 90 天断头,立即取出所有小脑。测定样本中丙二醛(MDA)和一氧化氮(NO)的含量,以及总超氧化物歧化酶(t-SOD)和谷胱甘肽过氧化物酶(GSH-px)的活性。与对照组相比,FA 处理组大鼠在生后第 30 天和第 90 天的 GSH-Px 活性、MDA 和 NO 水平均升高,t-SOD 活性降低。总的来说,第 90 天的结果与第 30 天相似。此外,我们观察到 12ppm FA 吸入组大鼠比 6ppm FA 吸入组大鼠受影响更大,尤其是在第 30 天。因此,本研究结果表明,新生期吸入 FA 以剂量相关的方式影响大鼠小脑的氧化应激和抗氧化系统,并增加某些自由基。我们认为这些变化会持续很长时间,或者可能导致不可逆转的毒性和氧化损伤。

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