Influence of diallyl disulphide on temporal patterns of circulatory lipid peroxidation products and antioxidants in N-nitrosodiethylamine-induced hepatocarcinogenesis in rats.

ABSTRACT Investigations on the effects of diallyl disulphide (60 mg/kg body weight) orally administered (thrice a week) on the temporal patterns of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) during N-Nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis were performed in rats. The acrophase of TBARS was found to be delayed and of antioxidants was found to be advanced in NDEA-treated rats. The increase in mesor of TBARS, decrease in mesor of antioxidants, and altered amplitude and acrophase indicated the negative imbalance of oxidant and antioxidant occurring during carcinogenesis. Oral treatment of diallyl disulphide (DADS) results in the resynchronization of the altered rhythms of TBARS and other antioxidants. Although NDEA has no known significant effects on the suprachaismatic nucleus (SCN), from the present results it could be hypothesized that it would influence the peripheral oscillator systems, such as liver, possibly by modulating secretion of the various hormones and growth factors during hepatocarcinogenesis.