Department of Obstetrics and Gynecology, Assiut University, Assiut, Egypt.
Acta Obstet Gynecol Scand. 2010;89(1):143-6. doi: 10.3109/00016340903289892.
Abstract The aim of this study was to identify pregnant women at risk of preeclampsia (PE) before clinical manifestations appeared using a panel of serum markers. We recruited 240 consecutive women who presented for antenatal care. We investigated whether serum levels of placental growth factor (PlGF), its inhibitor, soluble fms-like tyrosine kinase-1 (sFlt-1), measured at 13-16 weeks gestation and the expression of fms-like tyrosine kinase-1 (Flt-1) in the maternal neutrophils measured by flow cytometry could be predictive of the subsequent development of PE. Serum PlGF levels were found to be significantly lower among women who developed PE than patients with gestational hypertension or patients in the control group (p < 0.001). In contrast, serum sFlt1 levels were most elevated in patients who developed PE versus those with gestational hypertension or the control group (p < 0.001). Serum levels of neutrophil-Flt-1, however, were lower in women who developed PE than in those with gestational hypertension or those in the control group (p < 0.001). Increased serum levels of sFlt-1, decreased levels of neutrophil-Flt-1, and decreased levels of PlGF may predict women at risk of developing PE later in pregnancy.
摘要 本研究旨在通过一组血清标志物，在出现临床症状之前识别出有先兆子痫 (PE) 风险的孕妇。我们招募了 240 名连续就诊的孕妇。我们研究了在 13-16 周妊娠时测量的胎盘生长因子 (PlGF)、其抑制剂可溶性 fms 样酪氨酸激酶-1 (sFlt-1) 的血清水平以及通过流式细胞术测量的母体中性粒细胞中的 fms 样酪氨酸激酶-1 (Flt-1) 的表达，是否可以预测随后发生的 PE。结果发现，发生 PE 的女性血清 PlGF 水平明显低于妊娠高血压患者或对照组患者（p<0.001）。相比之下，发生 PE 的患者血清 sFlt1 水平明显高于妊娠高血压患者或对照组患者（p<0.001）。然而，发生 PE 的女性中性粒细胞-Flt-1 血清水平低于妊娠高血压患者或对照组患者（p<0.001）。血清 sFlt-1 水平升高、中性粒细胞-Flt-1 水平降低和 PlGF 水平降低可能预示着孕妇在妊娠后期有发生 PE 的风险。
