[标准化摄取值在 FDG PET-CT 预测放射性肺炎中的应用]
[Application of standardized uptake value for FDG PET-CT in predicting radiation pneumonitis].
作者信息
Zhang Yong, Yu Yong-hua, Yu Jin-ming, He Wei, Fu Zheng, Guo Shou-fang, Liu Xi-jun, Cong Chang-sheng
机构信息
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan 250117, China.
出版信息
Zhonghua Zhong Liu Za Zhi. 2009 Aug;31(8):622-5.
OBJECTIVE
To investigate the correlation of radiation pneumonitis (RP) with standardized uptake value (SUV) for fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET-CT) in lung cancer patients treated with radiation therapy.
METHODS
Fourty patients with unresectable non-small cell lung cancer (NSCLC) received FDG PET-CT before and after radiotherapy. The average SUV of the lung tissue irradiated with a dose of < or = 5 Gy, 5.1 approximately 15 Gy, 15.1 approximately 35 Gy, 35.1 approximately 60 Gy, >60 Gy were measured. The correlation between SUV and RP was analyzed by comparing the SUV in the patients with RP and without. The SUV ratio of the irradiated lung tissue to that of the non-irradiated lung tissue (L/B) was also calculated.
RESULTS
Of the 40 patients, 8 developed RP, including 6 cases of grade 2 and 2 cases of grade 3. The SUV of irradiated lung tissues with a dose of 35.1 approximately 60 Gy was significantly correlated with RP. When SUV > or =1, the RP incidence rate was 41.7% versus 20.0% in the whole group, with a statistically significant difference. (chi2 = 3.96, P < 0.05). The sensitivity and specificity of SUV in predicting RP was 62.5% and 78.1%, respectively. When the value of L/B > or = 2.5, the RP incidence rate was 40.7% in this group versus 20.0% in the whole group, with a statistical significance (chi(2) = 4.92, P < 0.05). If taking L/B > or = 2.5 as a threshold value, the sensitivity and specificity in predicting RP was 72.7% and 90.9%, respectively. No statistically significant difference was found in predicting radiation pneumonitis between SUV > or =1 and L/B > or = 2.5 (chi2 = 0.002, P > 0.05).
CONCLUSION
The standardized uptake value (SUV) and the SUV ratio of the irradiated lung tissue to that of the non-irradiated lung tissue (L/B) for FDG PET-CT are positively correlated with radiation pneumonitis, and clinicians may use it to predict the occurrence of radiation pneumonitis.
目的
探讨接受放射治疗的肺癌患者放射性肺炎（RP）与氟脱氧葡萄糖（FDG）正电子发射断层扫描及计算机断层扫描（PET-CT）标准化摄取值（SUV）之间的相关性。
方法
40例不可切除的非小细胞肺癌（NSCLC）患者在放疗前后接受了FDG PET-CT检查。测量了剂量≤5 Gy、5.1～15 Gy、15.1～35 Gy、35.1～60 Gy、＞60 Gy照射的肺组织的平均SUV。通过比较发生RP和未发生RP患者的SUV来分析SUV与RP之间的相关性。还计算了照射肺组织与未照射肺组织的SUV比值（L/B）。
结果
40例患者中，8例发生RP，其中2级6例，3级2例。剂量为35.1～60 Gy照射的肺组织的SUV与RP显著相关。当SUV≥1时，RP发生率在该组为41.7%，而在整个组中为20.0%，差异有统计学意义（χ2 = 3.96，P < 0.05）。SUV预测RP的敏感性和特异性分别为62.5%和78.1%。当L/B≥2.5时，该组RP发生率为40.7%，而在整个组中为20.0%，差异有统计学意义（χ2 = 4.92，P < 0.
Zotero 插件