Aronowitz Jesse N, Robison Roger F
Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Brachytherapy. 2010 Apr-Jun;9(2):178-84. doi: 10.1016/j.brachy.2009.10.001. Epub 2009 Dec 22.
Exploration of Howard Atwood Kelly's contributions to gynecologic brachytherapy.
Review of contemporary journals, texts, newspaper accounts, and the memoirs of Kelly's associates. Information from unpublished material, including Kelly's handwritten notes and diaries, was culled from the Alan Mason Chesney Archives of the Johns Hopkins Medical Institutions.
Despite European reports of radium's efficacy, gynecologists on both sides of the Atlantic resisted its adoption. The endorsement of radium therapy by America's foremost gynecologist, Howard Kelly, was instrumental in its acceptance. His consummate skill as clinician, investigator, publicist, and entrepreneur established brachytherapy as the primary treatment modality for carcinoma of the cervix and vagina. The technique he pioneered in the second decade of the 20th century, a combination of brachytherapy and megavoltage-equivalent teletherapy, presaged modern practice.
Principles for the management of female genital neoplasia, outlined by Howard Kelly nine decades ago, remain relevant today.
探究霍华德·阿特伍德·凯利对妇科近距离放射治疗的贡献。
查阅当代期刊、教科书、报纸报道以及凯利同事的回忆录。未发表材料中的信息，包括凯利的手写笔记和日记，是从约翰霍普金斯医疗机构的艾伦·梅森·切斯尼档案中搜集而来的。
尽管欧洲有关于镭疗效的报道，但大西洋两岸的妇科医生都抵制采用镭治疗。美国顶尖妇科医生霍华德·凯利对镭疗法的认可，对其被接受起到了推动作用。他作为临床医生、研究者、宣传者和企业家的精湛技艺，使近距离放射治疗成为子宫颈癌和阴道癌的主要治疗方式。他在20世纪第二个十年开创的技术，即近距离放射治疗与兆伏当量远距放射治疗相结合，预示了现代治疗方法。
霍华德·凯利在九十年前概述的女性生殖器官肿瘤管理原则，至今仍然适用。
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