Department of Surgery and Center for Quality and Safety, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA.
J Thorac Cardiovasc Surg. 2010 Feb;139(2):273-82. doi: 10.1016/j.jtcvs.2009.09.007. Epub 2009 Dec 22.
This study examines the association of hospital coronary artery bypass procedural volume with mortality, morbidity, evidence-based care processes, and Society of Thoracic Surgeons composite score.
The study population consisted of 144,526 patients from 733 hospitals that submitted data to the Society of Thoracic Surgeons Adult Cardiac Database in 2007. End points included use of National Quality Forum-endorsed process measures (internal thoracic artery graft; preoperative beta-blockade; and discharge beta-blockade, antiplatelet agents, and lipid drugs), operative mortality (in-hospital or 30-day), major morbidity (stroke, renal failure, reoperation, sternal infection, and prolonged ventilation), and Society of Thoracic Surgeons composite score. Procedural volume was analyzed as a continuous variable and by volume strata (< 100, 100-149, 150-199, 200-299, 300-449, and > or = 450). Analyses were performed with logistic and multivariate hierarchical regression modeling.
Unadjusted mortality decreased across volume categories from 2.6% (< 100 cases) to 1.7% (> 450 cases, P < .0001), and these differences persisted after risk factor adjustment (odds ratio for lowest- vs highest-volume group, 1.49). Care processes and morbidity end points were not associated with hospital procedural volume except for a trend (P = .0237) toward greater internal thoracic artery use in high-volume hospitals. The average composite score for the lowest volume (< 100 cases) group was significantly lower than that of the 2 highest-volume groups, but only 1% of composite score variation was explained by volume.
A volume-performance association exists for coronary artery bypass grafting but is weaker than that of other major complex procedures. There is considerable outcomes variability not explained by hospital volume, and low volume does not preclude excellent performance. Except for internal thoracic artery use, care processes and morbidity rates were not associated with volume.
本研究旨在探讨医院冠状动脉旁路移植术(CABG)的例数与死亡率、发病率、循证护理流程以及胸外科医师协会(STS)综合评分之间的关系。
研究人群来自于 2007 年向胸外科医师协会成人心脏数据库提交数据的 733 家医院的 144526 名患者。研究终点包括使用国家质量论坛认可的流程指标(内乳动脉移植物;术前β受体阻滞剂;出院时β受体阻滞剂、抗血小板药物和降脂药物)、手术死亡率(院内或术后 30 天内)、主要发病率(中风、肾衰竭、再次手术、胸骨感染和长时间通气)以及 STS 综合评分。手术例数以连续变量和分层(<100、100-149、150-199、200-299、300-449 和≥450)进行分析。采用逻辑回归和多变量层次回归模型进行分析。
未经校正的死亡率随着手术例数的增加而降低,从<100 例的 2.6%降至>450 例的 1.7%(P<.0001),在危险因素校正后这种差异仍然存在(最低与最高手术例数组的比值比为 1.49)。除了有使用内乳动脉的趋势(P=.0237)外,护理流程和发病率终点与医院手术例数无关。最低手术例数组(<100 例)的平均综合评分明显低于 2 个最高手术例数组,但只有 1%的综合评分差异可由例数解释。
虽然 CABG 存在手术例数与手术效果的相关性,但这种相关性比其他主要复杂手术弱。虽然有相当大的结果变异性无法用医院例数来解释,但低例数并不排除优秀的手术效果。除了内乳动脉的使用情况外,护理流程和发病率与例数无关。