双相障碍患者及其一级亲属的垂体体积。
Pituitary volume in patients with bipolar disorder and their first-degree relatives.
机构信息
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia.
出版信息
J Affect Disord. 2010 Aug;124(3):256-61. doi: 10.1016/j.jad.2009.12.002. Epub 2009 Dec 22.
BACKGROUND
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been reported in bipolar disorder (BD), but previous magnetic resonance imaging (MRI) studies of pituitary gland volume in BD have yielded inconsistent findings. In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown.
METHOD
We used MRI to investigate the pituitary volume in 29 remitted patients with BD, 49 of their first-degree relatives (of whom 15 had a diagnosis of Major Depressive Disorder), and 52 age- and gender-matched healthy controls.
RESULTS
BD patients had a significantly larger pituitary volume compared with their relatives and healthy controls. Pituitary volume did not differ between controls and healthy relatives or relatives diagnosed with major depression.
LIMITATIONS
Direct measures of HPA function (i.e., hormonal levels) were not available.
CONCLUSIONS
These findings suggest that enlarged pituitary volume is associated with disease expression but not genetic susceptibility to BD.
背景
双相障碍（BD）患者的下丘脑-垂体-肾上腺（HPA）轴功能失调已有报道，但此前关于 BD 患者垂体体积的磁共振成像（MRI）研究结果并不一致。此外，遗传因素对 BD 患者垂体变化的影响在很大程度上仍不清楚。
方法
我们使用 MRI 对 29 名缓解期 BD 患者、49 名其一级亲属（其中 15 名患有重度抑郁症）和 52 名年龄和性别匹配的健康对照者的垂体体积进行了研究。
结果
BD 患者的垂体体积明显大于其亲属和健康对照者。健康对照者和健康亲属之间以及亲属中被诊断为重度抑郁症者之间的垂体体积没有差异。
局限性
无法进行 HPA 功能的直接测量（即激素水平）。
结论
这些发现表明，垂体体积增大与疾病表现有关，而与 BD 的遗传易感性无关。
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