Department of Surgery, University of Pecs, Hungary.
In Vivo. 2009 Nov-Dec;23(6):975-8.
Cancer therapies and cancer progression can increase oxidative stress that might account for renal toxicity in cancer patients. Flavin 7 (F7) is a natural polyphenol-containing dietary supplement with potential antioxidant activity. Therefore, it might help to attenuate renal toxicity of chemotherapeutics.
Cultured mouse renal proximal tubule cells were subjected to H(2)O(2)-mediated oxidative stress. Potential antioxidant effects of F7 were assessed by measuring the production of reactive oxygen species (ROS), mitochondrial depolarization and injury (lactate dehydrogenase release as well as trypan blue exclusion) in cells that were pretreated with F7 prior to treatment with H(2)O(2).
F7 pretreatment significantly attenuated H(2)O(2)-induced ROS production, mitochondrial depolarization and consequent injury in renal proximal tubule cells.
F7 supplementation might be beneficial for cancer patients in order to prevent renal toxicity of anticancer drug- or cancer progression-related oxidative stress.
癌症治疗和癌症进展会增加氧化应激，这可能是癌症患者发生肾毒性的原因。黄素 7（F7）是一种天然的含多酚的膳食补充剂，具有潜在的抗氧化活性。因此，它可能有助于减轻化疗药物的肾毒性。
将培养的小鼠肾近端小管细胞暴露于 H（2）O（2）介导的氧化应激下。通过测量 F7 预处理后再用 H（2）O（2）处理的细胞中活性氧（ROS）的产生、线粒体去极化和损伤（乳酸脱氢酶释放以及台盼蓝排除）来评估 F7 的潜在抗氧化作用。
F7 预处理显著减轻了 H（2）O（2）诱导的肾近端小管细胞 ROS 产生、线粒体去极化和随后的损伤。
补充 F7 可能对癌症患者有益，以预防抗癌药物或癌症进展相关氧化应激引起的肾毒性。
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