Prescrire Int. 2009 Dec;18(104):261-2.
(1) Iron-deficiency anaemia during pregnancy increases the risk of low birth weight and preterm birth; (2) In a randomised double-blind placebo-controlled trial, iron supplementation in pregnant women with haemoglobin levels of at least 13.2 g/100 ml at the beginning of the 2nd trimester was associated with low birth weight and maternal hypertension; (3) In a trial in women with haemoglobin levels of at least 11.5 g/100 ml who took supplemental iron, haemoglobin levels above 14.5 g/100 ml at 28 weeks of gestation were associated with an 8-fold increase in the risk of preterm birth and a 6-fold increase in the risk of low birth weight; (4) An epidemiological study showed a link between high maternal haemoglobin levels and low birth weight; (5) In practice, iron supplements should not be taken by pregnant women whose haemoglobin levels exceed 11 g/100 ml during the 1st and 3rd trimesters and 10.5 g/100 ml during the 2nd trimester.
(1) 孕期缺铁性贫血会增加低出生体重和早产的风险;(2) 在一项随机双盲安慰剂对照试验中,孕中期开始时血红蛋白水平至少为13.2 g/100 ml的孕妇补充铁剂与低出生体重和母亲高血压有关;(3) 在一项针对血红蛋白水平至少为11.5 g/100 ml且服用补充铁剂的女性的试验中,妊娠28周时血红蛋白水平高于14.5 g/100 ml与早产风险增加8倍和低出生体重风险增加6倍有关;(4) 一项流行病学研究表明母亲血红蛋白水平高与低出生体重之间存在联系;(5) 在实际操作中,妊娠第一和第三孕期血红蛋白水平超过11 g/100 ml以及妊娠第二孕期血红蛋白水平超过10.5 g/100 ml的孕妇不应服用铁补充剂。