精神分裂症易感基因的小鼠模型中的认知。
Cognition in mouse models of schizophrenia susceptibility genes.
机构信息
Department of Neuroscience, Columbia University Medical Center, New York, NY 10032, USA.
出版信息
Schizophr Bull. 2010 Mar;36(2):289-300. doi: 10.1093/schbul/sbp153. Epub 2009 Dec 21.
Abstract
Cognitive deficits are core features of psychiatric disorders and contribute substantially to functional outcome. It is still unclear, however, how cognitive deficits are related to underlying genetic liability and overt clinical symptoms. Fortunately, animal models of susceptibility genes can illuminate how the products of disease-associated genetic variants affect brain function and ultimately alter behavior. Using as a reference findings from the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia program and the SchizophreniaGene database, we review cognitive data from mutant models of rare and common genetic variants associated with schizophrenia.
摘要
认知缺陷是精神疾病的核心特征，对功能结果有很大影响。然而，认知缺陷与潜在的遗传易感性和明显的临床症状之间的关系仍不清楚。幸运的是，易感基因的动物模型可以阐明与疾病相关的遗传变异体的产物如何影响大脑功能，并最终改变行为。本文以认知神经科学治疗研究改善精神分裂症认知的研究计划和精神分裂症基因数据库的研究结果为参考，综述了与精神分裂症相关的罕见和常见遗传变异体的突变模型的认知数据。
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