Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina.
Nat Rev Cancer. 2010 Jan;10(1):65-76. doi: 10.1038/nrc2681.
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.
转录因子之间的合作对于它们执行特定转录程序的能力至关重要。AP1 复合物就是一个转录因子网络的范例,在正常情况下和肿瘤发生发展过程中,它们协同发挥作用。本观点总结了我们目前对 AP1 复合物成员变化的认识,以及 ATF2 作为该复合物一部分在肿瘤发生中的作用。