手性多糖柱拆分苯并唑类和苯甲酰苯胺类对映体。

Enantioseparation of benzazoles and benzanilides on polysaccharide-based chiral columns.

机构信息

Department of Process Research, Merck Research Laboratories, Merck & Co., Inc, Tsukuba, Ibaraki 300-2611, Japan.

出版信息

Chirality. 2010 May 5;22(4):382-8. doi: 10.1002/chir.20732.

DOI:10.1002/chir.20732

PMID:20029961

Abstract

The chiral recognition ability of the polysaccharide-based chiral columns (Chiralpak AD-RH, Chiralpak AS-RJ, Chiralpak IC, Chiralcel OD-RH, and Chiralcel OJ-RH) for the benzazoles and the benzanilides was evaluated under reversed phase conditions. The columns showed the high chiral recognition ability for a wide range of benzazoles and benzanilides. Twenty-one racemates were used for the evaluation, and 20 racemates were completely separated on at least one of the columns. In particular, AS-RH and OJ-RH showed the high chiral recognition ability for the benzazoles, and the AD-RH, IC, and OJ-RH were effective for the benzanilides.

摘要

在反相条件下，评价了多糖手性柱（Chiralpak AD-RH、Chiralpak AS-RJ、Chiralpak IC、Chiralcel OD-RH 和 Chiralcel OJ-RH）对苯并唑和苯甲酰胺的手性识别能力。这些柱子对广泛的苯并唑和苯甲酰胺表现出了高的手性识别能力。使用了 21 个外消旋体进行评估，至少有一个柱子能够完全分离 20 个外消旋体。特别是 AS-RH 和 OJ-RH 对苯并唑具有高的手性识别能力，而 AD-RH、IC 和 OJ-RH 则对苯甲酰胺有效。