[下诺夫哥罗德地区患肠胃炎学童中检测到的人杯状病毒的遗传多样性]

[Genetic diversity of human caliciviruses detected in schoolchildren with gastroenteritis in Nizhni Novgorod].

作者信息

Lukovnikova L B, Epifanova N V, Novikov D V, Novikova N A

出版信息

Vopr Virusol. 2009 Nov-Dec;54(6):24-8.

PMID:20030278

Abstract

A total of 2312 children admitted to the Nizhni Novgorod infectious disease hospitals for diagnosed acute gastroenteritis were examined using the RT-PCR. The detection rate of human caliciviruses was found to be 6.5% (range 1.2 to 11.2%). The population of calicivuruses presented with noroviruses genogroups I (16%) and II (81%), and sapoviruses (3%). Noroviruses genogroup II included genotypes GII.2 and GII.4 with a preponderance of the variant CII.4-2006b. The detected sapoviruses were clustered with sapoviruses GI.1, GI.2, and GII.1 by phylogenetic analysis.

摘要

对下诺夫哥罗德传染病医院收治的2312名被诊断为急性肠胃炎的儿童进行了逆转录聚合酶链反应（RT-PCR）检测。人杯状病毒的检出率为6.5%（范围为1.2%至11.2%）。杯状病毒群体包括I型诺如病毒基因组（16%）和II型诺如病毒基因组（81%）以及札幌病毒（3%）。II型诺如病毒基因组包括GII.2和GII.4基因型，其中以CII.4-2006b变异体为主。通过系统发育分析，检测到的札幌病毒与GI.1、GI.2和GII.1札幌病毒聚类。