Kim Il Du, Kang Dae Hwan, Choi Cheol Woong, Kim Hyung Wook, Jung Woo Jin, Lee Dong Hyun, Chung Chung Wook, Yoo Jin Ju, Ryu Je Ho
Department of Internal Medicine, Medical Research Institute, Pusan National University School of Medicine and Medical Research Institute, Yangsan, South Korea.
Scand J Gastroenterol. 2010;45(1):100-5. doi: 10.3109/00365520903410554.
Placement of a self-expandable metal stent is a palliative treatment of choice for patients with malignant gastric outlet obstruction (GOO). Although covering an enteral stent with a membrane almost solves the problem of tumor ingrowth, stent migration continues to be a major unresolved problem. Our aim was to evaluate the clinical efficacy of endoscopic clipping for prevention of covered stent migration in the treatment of malignant GOO.
A total of 25 consecutive patients with malignant GOO were evaluated prospectively. After deployment of a double-layered combination stent (comprising an outer uncovered stent and an inner covered stent), three endoscopic clips were applied for fixation of the proximal end of the enteral stent to the gastric or duodenal mucosa.
Technical and clinical success rates were 100% (25/25) and 88% (22/25), respectively. No stent migration was observed in any of the patients. Five patients (20%) experienced complications such as tumor overgrowth and stent compression.
Endoscopic clipping for enteral stent placement seems to be effective for prevention of covered stent migration in patients with malignant GOO.
自膨式金属支架置入术是恶性胃出口梗阻(GOO)患者的首选姑息治疗方法。尽管用膜覆盖肠内支架几乎解决了肿瘤向内生长的问题,但支架迁移仍然是一个主要的未解决问题。我们的目的是评估内镜夹闭术在治疗恶性GOO中预防覆膜支架迁移的临床疗效。
前瞻性评估25例连续性恶性GOO患者。在置入双层组合支架(由外部未覆膜支架和内部覆膜支架组成)后,应用三个内镜夹将肠内支架近端固定于胃或十二指肠黏膜。
技术成功率和临床成功率分别为100%(25/25)和88%(22/25)。所有患者均未观察到支架迁移。5例患者(20%)出现肿瘤过度生长和支架压迫等并发症。
内镜夹闭术用于肠内支架置入似乎对预防恶性GOO患者的覆膜支架迁移有效。