山羊尿石症发作期鸟粪石和鸟粪石-K 晶体的沉淀研究。

Study on precipitation of struvite and struvite-K crystal in goats during onset of urolithiasis.

机构信息

Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing 210095, China.

出版信息

Res Vet Sci. 2010 Jun;88(3):461-6. doi: 10.1016/j.rvsc.2009.11.010. Epub 2009 Dec 23.

DOI:10.1016/j.rvsc.2009.11.010

PMID:20031181

Abstract

To learn more about the biomineralization process of struvite in ruminants, a seldom noticeable crystal, struvite-K, was investigated in six goats in which urolithiasis was induced by feeding a cottonseed meal and rice straw diet supplemented with MgO. The compositions of crystals and calculi were studied by chemical qualitative analysis and X-ray energy dispersive spectrometry (EDS). The activity product (AP) and relative supersaturation (RSS) of magnesium ammonium phosphate (MAP) and potassium magnesium phosphate (MKP) were calculated to compare the difference of crystals formed in this process. The results showed that calculi consisted of MAP with a little MKP. Crystals in the urine consisted of MAP and MKP before stone formation, but crystals in urine after stone formation mainly consisted of MKP. The AP and RSS of MAP and MKP significantly decreased after stone formation. It was concluded that MAP and MKP may coexist in the crystals of urine before struvite calculi formation but MKP did not precipitate to struvite calculi and was separated out as crystal sedimentation of urine. The changes of crystallization of MAP and MKP contributed partially to the supersaturation status of MAP and MKP during struvite stone formation.

摘要

为了更多地了解反刍动物中鸟粪石的生物矿化过程，研究了在 6 只山羊中一种很少被注意到的晶体——鸟粪石-K。这些山羊通过喂食添加了 MgO 的棉籽粉和稻草日粮来诱发尿石症。通过化学定性分析和 X 射线能量色散光谱（EDS）研究了晶体和结石的成分。计算了镁铵磷酸盐（MAP）和磷酸钾镁（MKP）的活度积（AP）和相对过饱和度（RSS），以比较该过程中形成的晶体的差异。结果表明，结石由含有少量 MKP 的 MAP 组成。结石形成前尿液中的晶体由 MAP 和 MKP 组成，但结石形成后尿液中的晶体主要由 MKP 组成。MAP 和 MKP 的 AP 和 RSS 在结石形成后显著降低。结论是，MAP 和 MKP 可能在鸟粪石结石形成前的尿液晶体中共同存在，但 MKP 不会沉淀为鸟粪石结石，而是作为尿液晶体沉淀物分离出来。MAP 和 MKP 的结晶变化部分导致了鸟粪石结石形成过程中 MAP 和 MKP 的过饱和度状态。