Giugliano D, Cozzolino D, Torella R, Lefebvre P J, Franchimont P, D'Onofrio F
Chair of Diabetology, First Faculty of Medicine, University of Naples, Italy.
Acta Endocrinol (Copenh). 1991 Feb;124(2):159-65. doi: 10.1530/acta.0.1240159.
The responses of plasma glucose, insulin, C-peptide and glucagon to an infusion of human beta-endorphin (0.5 mg/h) were studied in 10 formerly obese subjects who had lost 35 kg by dieting (body mass index less than 25) and compared with those of 10 normal-weight control (body mass index less than 25) and 10 obese (body mass index greater than 30) subjects. The fasting plasma concentrations of beta-endorphin were significantly higher in both the obese and the post-obese group than in the control group. In both obese and post-obese subjects, the infusion of beta-endorphin caused significant increases in peripheral plasma glucose, insulin, C-peptide and glucagon concentrations. In the control group, matched for age, sex and weight with the formerly obese group, there was no appreciable change in plasma insulin and C-peptide concentrations during the infusion of beta-endorphin, but the rise in plasma glucose was more sustained. Thus, 1. the increased plasma beta-endorphin concentrations found in human obesity are not corrected by normalization of body weight; and 2. formerly obese, normal-weight subjects behave as obese subjects in their metabolic and hormonal responses to beta-endorphin infusion. The alteration of the opioid system in human obesity may play some role in the predisposition to weight gain.
对10名通过节食减重35千克（体重指数小于25）的肥胖症康复者、10名体重正常的对照者（体重指数小于25）和10名肥胖者（体重指数大于30），研究了静脉输注人β-内啡肽（0.5毫克/小时）后血浆葡萄糖、胰岛素、C肽和胰高血糖素的反应。肥胖组和肥胖症康复组的空腹血浆β-内啡肽浓度均显著高于对照组。在肥胖者和肥胖症康复者中，输注β-内啡肽均导致外周血浆葡萄糖、胰岛素、C肽和胰高血糖素浓度显著升高。在与肥胖症康复组年龄、性别和体重相匹配的对照组中，输注β-内啡肽期间血浆胰岛素和C肽浓度无明显变化，但血浆葡萄糖的升高更持久。因此，1. 人类肥胖症中发现的血浆β-内啡肽浓度升高不会因体重恢复正常而得到纠正；2. 肥胖症康复后体重正常的受试者在对β-内啡肽输注的代谢和激素反应方面与肥胖受试者表现相同。人类肥胖症中阿片系统的改变可能在体重增加的易感性中起一定作用。
