Eginition University Hospital, 1st Department of Psychiatry, Medical School, National University of Athens, 74 Vas. Sophias ave., 115 28 Athens, Greece.
Behav Brain Funct. 2009 Dec 24;5:51. doi: 10.1186/1744-9081-5-51.
Recent research recognizes the association between handedness, linguistic processes and cerebral networks subserving executive functioning, but the nature of this association remains unclear. Since the P50 event related potential (ERP) is considered to reflect thalamocortical processes in association with working memory (WM) operation the present study focuses on P50 patterns elicited during the performance of a linguistic related executive functioning test in right- and left-handers.
In 64 young adults with a high educational level (33 left-handed) the P50 event-related potential was recorded while performing the initiation and inhibition condition of a modified version of the Hayling Sentence Completion test adjusted to induce WM. The manual preference of the participants was evaluated with the use of the Edinburgh Handedness Inventory (EHI).
P50 showed greater amplitudes in left- than in right-handers, mainly in frontal leads, in the initiation condition. Reduced amplitudes in inhibition compared to initiation condition were observed in left-handers. Low Resolution Electromagnetic Tomography (LORETA) analysis showed lower frontal lobe activation in the inhibition than in the initiation condition in both right- and left-handers. Also, LORETA yielded that right-handers exhibited greater activation in the inhibition condition than left-handers. Additionally, LORETA showed assymetrical hemispheric activation patterns in right-handers, in contrast to symmetrical patterns observed in left-handers. Higher P50 amplitudes were recorded in right-hemisphere of right-handers in the initiation condition.
Brain activation, especially the one closely related to thalamocortical function, elicited during WM operation involving initiation and inhibition processes appears to be related to handedness.
最近的研究认识到手性、语言过程和执行功能的大脑网络之间的关联，但这种关联的性质仍不清楚。由于 P50 事件相关电位（ERP）被认为反映了与工作记忆（WM）操作相关的丘脑皮质过程，因此本研究集中在右利手和左利手执行语言相关功能测试期间诱发的 P50 模式。
在 64 名具有高教育水平的年轻人中（33 名左利手），在执行 Hayling 句子完成测试的启动和抑制条件时记录 P50 事件相关电位，该测试经过调整以诱导 WM。参与者的手动偏好使用爱丁堡手性量表（EHI）进行评估。
P50 在左利手中的振幅大于右利手，主要在前额导联，在启动条件下。在抑制条件下与启动条件相比，振幅减小。低分辨率电磁断层扫描（LORETA）分析显示，在启动和抑制条件下，左利手的额叶激活度均较低。此外，LORETA 还表明，在抑制条件下，右利手的激活度大于左利手。此外，LORETA 显示右利手的半球激活模式不对称，而左利手的半球激活模式则对称。在启动条件下，右利手的右半球记录到较高的 P50 振幅。
在涉及启动和抑制过程的 WM 操作期间诱发的大脑激活，特别是与丘脑皮质功能密切相关的激活，似乎与手性有关。
