Woimant France
Service de neurologie, Hôpital Lariboisière, 2 rue Ambroise Paré, F-75010 Paris, France.
Presse Med. 2010 Feb;39(2):254-62. doi: 10.1016/j.lpm.2009.03.021. Epub 2010 Jan 14.
Atherosclerotic carotid stenosis is a risk factor for myocardial infarction, for vascular death, and for stroke. Medical treatment for atherosclerotic carotid stenosis routinely includes screening for and treatment of both risk factors and other atherosclerotic sites, the prescription of antiplatelets drugs, and patient education about transient ischemic accidents. The benefits of carotid surgery have been demonstrated in symptomatic stenoses with stenosis of 70% or more. In women, the benefits of surgery are slight for asymptomatic stenosis exceeding > 60% and for moderate symptomatic stenosis (50-69%). The treatment decision requires consideration of individual factors such as age, characteristics of the stenosis, and the type of symptoms (hemispheric or retinal). Carotid angioplasty is not yet sufficiently safe to replace endarterectomy in patients with atherosclerotic carotid stenosis. It can be proposed only after multidisciplinary consultation for patients at high risk of recurrence under medical treatment and in cases of major comorbidity contraindicating carotid surgery or of upper cervical stenosis not accessible to surgery.
动脉粥样硬化性颈动脉狭窄是心肌梗死、血管性死亡和中风的危险因素。动脉粥样硬化性颈动脉狭窄的药物治疗通常包括筛查和治疗危险因素及其他动脉粥样硬化部位、开具抗血小板药物以及对患者进行短暂性脑缺血发作的教育。颈动脉手术的益处已在狭窄程度达70%或更高的有症状狭窄中得到证实。对于女性,手术对于无症状狭窄超过60%以及中度有症状狭窄(50 - 69%)的益处不大。治疗决策需要考虑个体因素,如年龄、狭窄特征以及症状类型(半球性或视网膜性)。在动脉粥样硬化性颈动脉狭窄患者中,颈动脉血管成形术的安全性尚不足以替代内膜切除术。仅在多学科会诊后,对于药物治疗复发风险高的患者以及存在重大合并症禁忌颈动脉手术或存在手术无法触及的上颈椎狭窄的情况下,才可以考虑颈动脉血管成形术。