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非体外循环冠状动脉搭桥术后肝素诱导的无血小板减少性血栓形成导致暴发性肺栓塞

Heparin-induced thrombosis without thrombocytopenia causing fulminant pulmonary embolism after off-pump coronary artery bypass grafting.

作者信息

Bigdeli Amir K, Schmitz Christoph, Bruegger Dirk, Weis Florian, Weis Marion, Michel Sebastian, Schmauss Daniel, Reichart Daniel, Reichart Bruno, Sodian Ralf

机构信息

Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr. 15, D-81377 München, Germany.

出版信息

Heart Surg Forum. 2009 Dec;12(6):E368-70. doi: 10.1532/HSF98.20091057.

Abstract

Heparin-induced thrombocytopenia (HIT) is a rare immune-mediated complication of heparin administration. A potentially life-threatening complication, HIT is difficult to diagnose in patients in the intensive care unit after cardiac surgery because there can be multiple reasons for thrombocytopenia. Moreover, immune-mediated platelet consumption may be masked by reactive thrombocytosis, which is common in the typical postoperative course after cardiac surgery. We report the case of a 57-year-old male patient who developed fulminant pulmonary embolism following heparin-induced thrombosis without thrombocytopenia after off-pump coronary artery bypass surgery.

摘要

肝素诱导的血小板减少症(HIT)是肝素治疗罕见的免疫介导并发症。作为一种潜在的危及生命的并发症,心脏手术后重症监护病房的患者很难诊断HIT,因为血小板减少可能有多种原因。此外,免疫介导的血小板消耗可能被反应性血小板增多症掩盖,这在心脏手术后的典型病程中很常见。我们报告了一例57岁男性患者,该患者在非体外循环冠状动脉搭桥手术后发生肝素诱导的血栓形成且无血小板减少症,随后出现暴发性肺栓塞。

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