Okazaki Satoshi, Uetake Hiroyuki, Yano Makoto, Ishiguro Megumi, Kobayashi Hirotoshi, Ishikawa Toshiaki, Iida Satoru, Higuchi Tetsuro, Yasuno Masamichi, Enomoto Masayuki, Sugihara Kenichi
Department of Surgical Oncology, and Graduate School, Tokyo Medical and Dental University.
Gan To Kagaku Ryoho. 2009 Nov;36(12):2163-5.
We report a case of rectal cancer with distant metastases, which was successfully treated with multidisciplinary treatments. The 60s female underwent an abdomino-perineal resection (APR) for low rectal cancer. One year after the APR, two hepatic metastases were found and initially treated by radiofrequency ablation and later by hepatectomy. One month after the hepatectomy, three pulmonary metastases of 10 mm in diameter were found in the right lung. Several regimens of chemotherapy (S-1, CPT-11 and FOLFOX6) were performed. After 3 years of chemotherapy, pulmonary metastases re- grew in size but no new lesion developed. Pneumonectomy was performed to remove all metastatic tumors. A half year after the initial pneumonectomy, a new metastasis was found in the left lung, which was again removed by surgery after 6 months of observation. Postoperative course was uneventful, and she is alive without recurrence for 7 years since the initial rectal surgery.
我们报告一例伴有远处转移的直肠癌病例,该病例通过多学科治疗成功治愈。这位60多岁的女性因低位直肠癌接受了腹会阴联合切除术(APR)。APR术后一年,发现两处肝转移,最初采用射频消融治疗,后来进行了肝切除术。肝切除术后一个月,在右肺发现三处直径为10毫米的肺转移。进行了几种化疗方案(S-1、CPT-11和FOLFOX6)。化疗3年后,肺转移瘤大小复发,但未出现新病灶。进行了肺切除术以切除所有转移瘤。初次肺切除术后半年,在左肺发现一处新转移灶,观察6个月后再次通过手术切除。术后过程顺利,自初次直肠手术以来,她已存活7年且无复发。