Malhi Gin, Adams Danielle, Plain Janice, Coulston Carissa, Herman Michael, Walter Garry
Discipline of Psychological Medicine, University of Sydney, Australia.
Australas Psychiatry. 2010 Feb;18(1):32-41. doi: 10.3109/10398560903254193.
The aim of this study was to identify the prevalence of metabolic syndrome and its putative precursors in a naturalistic study of non-acute inpatients at a psychiatric hospital.
Anthropometric and biochemical data collected from the hospital's annual cardiometabolic survey, along with information about prescribed medications, were used to assess the prevalence and predictors of physical health problems in patients with schizophrenia.
Of the 167 patients included in the survey, 52.4% met criteria for metabolic syndrome. A shorter duration of hospital admission and clozapine use were significant predictors of metabolic syndrome. Age, gender, duration of admission and clozapine use were all predictors of individual cardiometabolic risk factors.
The findings from this naturalistic study reinforce the high prevalence of physical health problems in patients with schizophrenia and the important influence that psychiatric treatments can have on physical health. The impact of clozapine on cardiometabolic health appears to occur early in the course of treatment and emphasizes the need for proactive monitoring and interventions from the outset of management.
本研究旨在通过对一家精神病医院非急性住院患者进行的自然主义研究，确定代谢综合征及其假定前驱症状的患病率。
从该医院年度心脏代谢调查中收集的人体测量和生化数据，以及有关所开药物的信息，用于评估精神分裂症患者身体健康问题的患病率和预测因素。
在纳入调查的167名患者中，52.4%符合代谢综合征标准。住院时间较短和使用氯氮平是代谢综合征的显著预测因素。年龄、性别、住院时间和氯氮平使用情况均为个体心脏代谢风险因素的预测因素。
这项自然主义研究的结果强化了精神分裂症患者身体健康问题的高患病率，以及精神科治疗对身体健康可能产生的重要影响。氯氮平对心脏代谢健康的影响似乎在治疗过程早期就会出现，并强调从管理开始就需要进行积极监测和干预。
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