Duara Rajnish, Misra Manoranjan, Bhuyan Ritwick Raj, Sarma P Sankara, Jayakumar Karunakaran
Department of Cardiovascular and Thoracic Surgery, Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala-695 011, India.
Asian J Transfus Sci. 2008 Jul;2(2):51-5. doi: 10.4103/0973-6247.42659.
Homologous blood transfusion after open heart surgery puts a tremendous load on the blood banks. This prospective randomized study evaluates the efficacy of infusing back residual cardiopulmonary bypass (CPB) circuit i.e., pump blood as a means to reduce homologous transfusion after coronary artery bypass surgery (CABG) and whether its use increases postoperative drainage.
Sixty-seven consecutive patients who underwent elective CABGs under CPB were randomized into 2 groups: (1) cases where residual pump blood was used and (2) controls where residual pump blood was not used. Patients were monitored for hourly drainage on the day of surgery and the 1(st) postoperative day and the requirements of homologous blood and its products. Data were matched regarding change in Hemoglobin, Packed Cell Volume and coagulation parameters till 1st postoperative day. All cases were followed up for three years.
There was a marginal reduction in bleeding pattern in the early postoperative period in the cases compared to controls. The requirement of homologous blood and its products were also reduced in the cases.
The use of CPB circuit blood is safe in the immediate postoperative period. The requirement of homologous blood transfusion can come down if strict transfusion criteria are maintained.
心脏直视手术后的同种异体输血给血库带来了巨大负担。这项前瞻性随机研究评估了回输体外循环(CPB)回路中的剩余血液,即泵血,作为减少冠状动脉旁路移植术(CABG)后同种异体输血的一种手段的疗效,以及其使用是否会增加术后引流量。
67例在CPB下接受择期CABG的连续患者被随机分为两组:(1)使用剩余泵血的病例组;(2)不使用剩余泵血的对照组。在手术当天和术后第1天对患者进行每小时引流量监测,并监测同种异体血及其制品的需求量。直至术后第1天,对血红蛋白、血细胞比容和凝血参数的变化数据进行匹配。所有病例均随访三年。
与对照组相比,病例组术后早期的出血情况略有减少。病例组对同种异体血及其制品的需求量也有所减少。
术后即刻使用CPB回路血液是安全的。如果维持严格的输血标准,同种异体输血的需求量可以降低。