Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Cattedra di Geriatria, Università degli Studi di Napoli Federico II, Naples, Italy.
Curr Pharm Des. 2009;15(36):4186-90. doi: 10.2174/138161209789909665.
Large doses of omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are used to treat several diseases including hypertriglyceridemia in humans. Modest levels of EPA and DHA may be obtained from food, particularly from fatty fish. This review presents the literature examining the differences between omega-3 fatty acid dietary supplementation and prescribed omega-3-acid ethyl esters (P-OM3). Reports published between 1995 and 2007 containing sources, recommended intake, and differences in the various formulations of omega-3 fatty acids were sought in PubMed and the Food and Drug Administration (FDA) Websites. However, lack of head-to-head clinical trials using both P-OM3 and dietary-supplement omega-3 fatty acids is the greatest limitation of this review. Although many kinds of omega-3 fatty acid dietary supplements are available, the efficacy, quality, and safety of these products are questionable because they are beyond any pharmaceutical control. Thus, P-OM3 is the only FDA approved omega-3 fatty acid product which is available in the United States as an adjunct to diet to improve human health.
大剂量的ω-3 脂肪酸二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）被用于治疗多种疾病，包括人类的高甘油三酯血症。适度的 EPA 和 DHA 可以从食物中获得，特别是从高脂肪鱼类中获得。本综述介绍了检查 ω-3 脂肪酸饮食补充剂和规定的 ω-3-酸乙酯（P-OM3）之间差异的文献。在 PubMed 和美国食品和药物管理局（FDA）网站上寻找了 1995 年至 2007 年期间发表的报告，这些报告包含来源、推荐摄入量以及各种 ω-3 脂肪酸配方的差异。然而，本综述的最大限制是缺乏同时使用 P-OM3 和饮食补充 ω-3 脂肪酸的头对头临床试验。尽管有许多种类的 ω-3 脂肪酸膳食补充剂，但这些产品的疗效、质量和安全性是值得怀疑的，因为它们不受任何药物控制。因此，P-OM3 是唯一获得美国 FDA 批准的 ω-3 脂肪酸产品，作为饮食的辅助手段在美国上市，以改善人类健康。
