Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Yamadaoka, Suita, Japan.
J Dent Res. 2010 Feb;89(2):138-42. doi: 10.1177/0022034509356045. Epub 2009 Dec 30.
The progression of periodontitis may be affected by ALDH2 genotypes with respect to the oxidation of acetaldehyde to acetate, which leads to the accumulation of acetaldehyde in plasma and potential toxic effects. We examined the prospective association of ALDH2 genotypes in terms of alcohol sensitivity between alcohol consumption and periodontal disease progression. In 2003, 224 of 256 (87.5%) individuals examined at baseline (1999) completed probing pocket depth measurements for the evaluation of periodontitis progression. Missing data on self-reported questionnaires and blood samples were excluded; therefore, 183 samples were analyzed. Individuals who consumed > or = 33.0 g/day of alcohol exhibited high periodontal disease progression risk (OR = 3.54). ALDH2 *1/*2 individuals who consumed > or = 33 g/day of alcohol displayed a significant odds ratio (OR = 4.28) of periodontitis progression risk, in contrast to ALDH2 *1/*1 individuals. These results suggested that alcohol consumption as well as alcohol sensitivity may be a risk factor for periodontitis progression.
牙周炎的进展可能受到 ALDH2 基因型的影响，因为该基因型与乙醛向乙酸的氧化有关，这会导致乙醛在血浆中的积累和潜在的毒性作用。我们研究了 ALDH2 基因型在酒精敏感性方面与酒精摄入和牙周病进展之间的前瞻性关联。在 2003 年，对 256 名参与者中的 224 名（87.5%）在基线（1999 年）时完成了探测袋深度测量，以评估牙周炎的进展。排除了自我报告问卷和血液样本中的缺失数据；因此，分析了 183 个样本。每天摄入 > = 33.0 克酒精的个体表现出较高的牙周病进展风险（OR = 3.54）。与 ALDH2 * 1/* 1 个体相比，每天摄入 > = 33 克酒精的 ALDH2 * 1/* 2 个体的牙周炎进展风险的比值比（OR）显著增加（OR = 4.28）。这些结果表明，酒精摄入和酒精敏感性可能是牙周炎进展的一个危险因素。
