Gordon Karen Ann, Valero Jerome, Jewell Stephanie F, Ahn Julia, Papsin Blake C
Archie's Cochlear Implant Laboratory, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
Neuroreport. 2010 Feb 17;21(3):163-7. doi: 10.1097/WNR.0b013e328331558a.
The auditory brainstem pathways require stimulation to mature, but do they develop in the absence of auditory input? To answer this, peaks of the electrically evoked auditory nerve (wave eN1) and brainstem response (eII, eIII, and eV) were measured in 117 children with early-onset deafness who had received cochlear implants. Data were collected at cochlear implant activation. In the absence of significant input, the interpeak latency eN1-eIII decreased over the first year of life but remained constant thereafter. Chronic cochlear implant stimulation was required to promote significant reduction in eIII-eV interpeak latency. Thus, activity-independent changes occurring in infancy are concentrated in the caudal auditory brainstem and likely involve the auditory nerve. Changes requiring input are most prevalent in rostral brainstem.
听觉脑干通路需要刺激才能成熟，但在没有听觉输入的情况下它们会发育吗？为了回答这个问题，对117名接受了人工耳蜗植入的早发性耳聋儿童测量了电诱发听神经（eN1波）和脑干反应（eII、eIII和eV）的峰值。数据在人工耳蜗激活时收集。在没有显著输入的情况下，eN1 - eIII峰间期在生命的第一年有所缩短，但此后保持稳定。需要长期的人工耳蜗刺激才能使eIII - eV峰间期显著缩短。因此，婴儿期发生的与活动无关的变化集中在尾侧听觉脑干，可能涉及听神经。需要输入的变化在头侧脑干最为普遍。
