Laboratorio de Imunopatologia, Nucleo de Medicina Tropical, UFPA, Belem-PA, Brazil.
Acta Trop. 2010 Apr;114(1):59-62. doi: 10.1016/j.actatropica.2009.12.005. Epub 2010 Jan 4.
Jorge Lobo's disease is a chronic infection caused by the fungus Lacazia loboi endemic in South America. The infection is characterized by the appearance of parakeloidal, ulcerated or verrucous nodular or plaque-like cutaneous lesions. The histopathological aspect is characterized by poorly organized granulomas with histiocytes and multinucleated giant cells. Little is known about local immune response in lobomycosis skin lesions. Thirty-three skin biopsies from patients with Jorge Lobo's disease were selected from Ambulatory of Dermatology, UFPA. The control group was constituted by ten biopsies from normal skin. Langerhans cells were identified by immunohistochemistry using anti-CD1a antibody (Serotec). The number of positive cells was statistically analyzed. Langerhans cells were visualized along the epidermis in biopsies from Jorge Lobo's disease and the morphology and the number of Langerhans cells did not differ from normal skin (p>0.05). In Jorge Lobo's disease, this cell population probably presents some escape mechanism of the local immune system to evade the antigen presentation by those cells.
豪尔赫·洛博病是一种由南美的拉卡西亚·洛博真菌引起的慢性感染。这种感染的特征是出现类副瘤样的、溃疡性或疣状结节状或斑块状皮肤损伤。组织病理学特征是组织细胞和多核巨细胞组成的组织肉芽肿排列不规则。对于豪尔赫·洛博病皮肤损伤中的局部免疫反应知之甚少。从 UFPA 的皮肤科门诊选择了 33 例患有豪尔赫·洛博病的患者皮肤活检，对照组由 10 例正常皮肤活检组成。使用抗 CD1a 抗体（Serotec）通过免疫组织化学鉴定朗格汉斯细胞。对阳性细胞的数量进行了统计学分析。在豪尔赫·洛博病的活检中，朗格汉斯细胞沿着表皮可视化，其形态和数量与正常皮肤无差异（p>0.05）。在豪尔赫·洛博病中，这些细胞群体可能具有某种局部免疫系统的逃逸机制，以逃避这些细胞的抗原呈递。
