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核苷二磷酸糖和其他多磷酸化生物缀合物的方便合成。

A convenient synthesis of nucleoside diphosphate glycopyranoses and other polyphosphorylated bioconjugates.

机构信息

Institute of Organic Chemistry, Department of Chemistry, Faculty of Sciences, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.

出版信息

Eur J Cell Biol. 2010 Jan;89(1):63-75. doi: 10.1016/j.ejcb.2009.10.013. Epub 2009 Dec 31.

DOI:10.1016/j.ejcb.2009.10.013

PMID:20045214

Abstract

In this review, we summarize results obtained using a conceptionally new chemical synthesis of NDP-sugars based on cycloSaligenyl (cycloSal) nucleotides as starting material (cycloSal technique). The cycloSal technique not only leads to stereoisomerically defined NDP-sugars in high yield, but the same principle provides very efficient routes towards nucleoside di- and -triphosphates. Moreover, sugar-nucleotides such as CMP-Neu5Ac and dinucleoside polyphosphates are available. Thus, the method offers a nearly universal chemical access towards a large number of highly interesting bioconjugates and biomolecules.

摘要

在这篇综述中，我们总结了使用基于环沙利基（cycloSaligenyl，cycloSal）核苷酸的新概念化学合成 NDP-糖的结果（cycloSal 技术）。cycloSal 技术不仅以高产率得到立体异构体定义明确的 NDP-糖，而且相同的原理还提供了核苷二磷酸和三磷酸的非常有效的途径。此外，还可以获得 CMP-Neu5Ac 和二核苷多磷酸等糖核苷酸。因此，该方法几乎可以通用地获得大量非常有趣的生物缀合物和生物分子。