Section of Gynecologic Oncology, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
Taiwan J Obstet Gynecol. 2009 Dec;48(4):370-4. doi: 10.1016/S1028-4559(09)60325-9.
To examine the relationship between human papillomavirus (HPV) and Epstein-Barr virus (EBV) infections in relation to age of patients with cervical adenocarcinoma.
Thirty samples of human cervical adenocarcinoma tissue were collected from the surgical pathology archive at Taipei Veterans General Hospital from 1996 to 2008. All samples were examined for EBV, HPV-16 and HPV-18 E6 DNA by conventional and real-time quantitative polymerase chain reaction assays.
HPV-16 DNA was detected in 10 cases (33.3%), HPV-18 DNA in 12 cases (40%), and EBV DNA in three cases (10%); there were negative findings in seven cases (23.3%). EBV combined with HPV-16 or HPV-18 was also detected in one case each. No link could be demonstrated between HPV and EBV in endocervical lesions. When 20 patients 45 years old were compared with 10 patients > 45 years old, HPV-18 E6 DNA was detected in 45% vs. 30% (9/20 vs. 3/10), HPV-16 E6 DNA in 40% vs. 20% (8/20 vs. 2/10), EBV DNA in 10% vs. 10% (2/20 vs. 1/10), and no virus DNA was detected in 10% vs. 50% (2/20 vs. 5/10). HPV and EBV were significantly more common in younger women (p < 0.001).
HPV-18 plays a major role in adenocarcinomas at any age. A high prevalence of HPV DNA is significantly associated with cervical adenocarcinoma, especially in younger women. The results do not support a role for EBV in cervical adenocarcinogenesis or any relationship between EBV and HPV infection in adenocarcinoma.
探讨人乳头瘤病毒（HPV）和 Epstein-Barr 病毒（EBV）感染与宫颈腺癌患者年龄的关系。
本研究收集了 1996 年至 2008 年期间台北荣民总医院外科病理档案中的 30 例宫颈腺癌组织样本。所有样本均通过常规和实时定量聚合酶链反应检测 EBV、HPV-16 和 HPV-18 E6 DNA。
10 例（33.3%）检测到 HPV-16 DNA，12 例（40%）检测到 HPV-18 DNA，3 例（10%）检测到 EBV DNA，7 例（23.3%）检测结果为阴性。还在 1 例中检测到 EBV 与 HPV-16 或 HPV-18 的联合感染。在宫颈内病变中，未发现 HPV 与 EBV 之间存在关联。与 45 岁以上的 10 例患者相比，20 例 45 岁以下的患者中 HPV-18 E6 DNA 的检出率为 45%（9/20）vs. 30%（3/10），HPV-16 E6 DNA 的检出率为 40%（8/20）vs. 20%（2/10），EBV DNA 的检出率为 10%（2/20）vs. 10%（1/10），而无病毒 DNA 的检出率为 10%（2/20）vs. 50%（5/10）。HPV 和 EBV 在年轻女性中更为常见（p<0.001）。
HPV-18 在任何年龄的腺癌中都发挥主要作用。HPV DNA 的高检出率与宫颈腺癌显著相关，尤其是在年轻女性中。结果不支持 EBV 在宫颈腺癌发生中的作用，也不支持 EBV 与腺癌中 HPV 感染之间的关系。
