Sutcliffe Trenna
Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario.
Paediatr Child Health. 2002 Sep;7(7):449-53. doi: 10.1093/pch/7.7.449.
Bacterial meningitis is an important infection of childhood with significant morbidity and mortality, and clinicians are faced with controversies over steroid use and fluid restriction in its initial management because the standard of practice is not clear. A 1999 survey of paediatric infectious diseases specialists demonstrated that only 56% of respondents recommended dexamethasone for Haemophilus influenzae type b meningitis and only 34% recommended dexamethasone for Streptococcus pneumoniae meningitis, despite recommendations for dexamethasone in the 1997 Red Book. The present article illustrates a typical case presentation of bacterial meningitis, and discusses dexamethasone use and fluid restriction. The use of intravenous fluid therapy is also reviewed, based on results from the single prospective randomized clinical trial in this area.
细菌性脑膜炎是一种在儿童期较为重要的感染性疾病,具有较高的发病率和死亡率。由于治疗规范尚不明确,临床医生在其初始治疗中面临着关于使用类固醇和液体限制的争议。1999年对儿科传染病专家进行的一项调查显示,尽管1997年的《红宝书》推荐使用地塞米松,但只有56%的受访者建议在b型流感嗜血杆菌脑膜炎中使用地塞米松,只有34%的受访者建议在肺炎链球菌脑膜炎中使用地塞米松。本文阐述了一例典型的细菌性脑膜炎病例,并讨论了地塞米松的使用和液体限制。基于该领域唯一一项前瞻性随机临床试验的结果,还对静脉输液治疗的应用进行了综述。