Kuz'min O B, Lebedev A A
Farmakol Toksikol. 1977 Sep-Oct;40(5):600-2.
Functional significance of alpha and beta-adrenoreceptors and also possible involvement of the cyclic 3', 5'-AMP in the catecholamines regulation mechanism of the sodium and potassium ions transport in renal cortex slices of rats were studied. Epinephrine did not change the intracellular sodium and water content, but increased that of potassium in the cells. Phentolamine-a blocking agent of the alpha-adrenoreceptors--did not change the reaction of slices to epinephrine, while inderal--a beta-adrenoblocking agent-prevented accumulation of potassium by the cells occurring under the action of epinephrine. Isopropyl-nore-pinephrine reproduced the action of epinephrine on the electrolytes composition of the renal tissue. It is suggested that accumulation of postassium by the cells of the rats' renal cortex slices is consequent upon excitation of the beta-adrenoreceptors.
研究了α和β肾上腺素能受体的功能意义,以及环3',5'-腺苷酸可能参与大鼠肾皮质切片中儿茶酚胺对钠和钾离子转运的调节机制。肾上腺素未改变细胞内钠和水的含量,但增加了细胞内钾的含量。α肾上腺素能受体阻断剂酚妥拉明未改变切片对肾上腺素的反应,而β肾上腺素能阻断剂心得安则阻止了肾上腺素作用下细胞对钾的积累。异丙基去甲肾上腺素重现了肾上腺素对肾组织电解质组成的作用。提示大鼠肾皮质切片细胞对钾的积累是β肾上腺素能受体兴奋的结果。