HPV16 E7 序列缺乏与 HPV31 和 HPV73 的异质性，可能与其独特的致癌特性有关。
Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA.
出版信息
Arch Virol. 2010 Mar;155(3):367-70. doi: 10.1007/s00705-009-0579-2. Epub 2010 Jan 6.
Abstract
To assess the role of human papillomavirus virus (HPV) genetics in cervical lesions, we sequenced the E7 gene of HPV16, 31, or 73 from singly infected women who (1) cleared the infection quickly, (2) had type-specific persistent infection, or (3) progressed to CIN2 or worse lesions. Four of the 296 HPV16 E7 nucleotides were variable, compared with 7 of 296 for HPV31 E7 and 4 of 296 for HPV73 E7. While most of the polymorphisms in HPV31 and -73 resulted in non-synonymous amino acid changes, the polymorphisms in the HPV16 E7 resulted in synonymous changes. The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16.
摘要
为了评估人乳头瘤病毒（HPV）遗传学在宫颈病变中的作用，我们对快速清除感染、具有特定持续性感染或进展为 CIN2 或更严重病变的单一感染妇女的 HPV16、31 或 73 的 E7 基因进行了测序。296 个 HPV16 E7 核苷酸中有 4 个是可变的，HPV31 E7 有 7 个，HPV73 E7 有 4 个。虽然 HPV31 和 -73 的大多数多态性导致非同义氨基酸变化，但 HPV16 E7 的多态性导致同义变化。HPV16 E7 的缺乏异质性表明存在高度进化的净化选择，这可能与 HPV16 的独特致癌性有关。
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