Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Basic Clin Pharmacol Toxicol. 2010 Mar;106(3):189-94. doi: 10.1111/j.1742-7843.2009.00510.x. Epub 2009 Dec 29.
The integrated glucose-insulin model was originally developed on a variety of intravenous glucose provocation experiments in healthy volunteers and type 2 diabetic patients. The model, which simultaneously describes time-courses of glucose and insulin based on mechanism-based components for production, elimination and homeostatic feedback, has been further extended to oral glucose provocations, meal tests and insulin administration. The model has been used to describe experiments ranging from 4 to 24 hr. Applications of the integrated glucose-insulin model include the clinical assessment of the mechanism of action of anti-diabetic drugs and the magnitude of their effects. Finally, the model was used for optimizing the design of provocation experiments.
整合的血糖-胰岛素模型最初是在健康志愿者和 2 型糖尿病患者的各种静脉内葡萄糖激发试验上开发的。该模型基于产生、消除和体内平衡反馈的机制成分同时描述葡萄糖和胰岛素的时程，已进一步扩展到口服葡萄糖激发、进餐试验和胰岛素给药。该模型已用于描述从 4 小时到 24 小时的实验。整合的血糖-胰岛素模型的应用包括临床评估抗糖尿病药物的作用机制及其作用的大小。最后，该模型用于优化激发试验的设计。
