van Dissel Jaap T, Coutinho Roel A, van der Sande Marianne A B
Leids Universitair Medisch Centrum, afd. Infectieziekten, Leiden, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:B486.
It has been suggested that it is unwise to employ neuraminidase inhibitors in order to diminish the risk of influenza-related complications in cases of infection with the new influenza A(H1N1). However, the major argument, i.e. that the beneficial effects shown in the published evidence may be due to age differences between treatment and placebo groups, can easily be refuted. The Netherlands' policy to limit treatment to those patient groups who are considered at high risk of influenza complications is a sound one. In addition, it is endorsed by recent guidelines of the WHO and CDC.
有人认为,在新型甲型H1N1流感感染病例中使用神经氨酸酶抑制剂以降低流感相关并发症的风险是不明智的。然而,主要论点,即已发表证据中显示的有益效果可能归因于治疗组和安慰剂组之间的年龄差异,很容易被反驳。荷兰将治疗限制在那些被认为有高流感并发症风险的患者群体的政策是合理的。此外,它得到了世界卫生组织和美国疾病控制与预防中心最近指南的认可。