Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA.
Psychother Psychosom. 2010;79(2):87-96. doi: 10.1159/000270916. Epub 2009 Dec 24.
Outcomes are frequently suboptimal for patients with bipolar disorder who are treated with pharmacotherapy alone. Adjunct exercise has the potential to substantially improve acute and long-term outcomes, although how exercise would improve the course of bipolar disorder needs to be elucidated. We propose that exercise may improve mood and functioning by increasing neurogenesis and reducing allostatic load. We review data suggesting that exercise increases levels of brain-derived neurotrophic factor, which in turn increases neurogenesis and decreases allostatic load. Exercise as a psychosocial adjunct for bipolar disorder should be assessed with rigorous randomized clinical trials.
对于仅接受药物治疗的双相情感障碍患者，其治疗结局往往并不理想。辅助运动疗法有可能显著改善双相情感障碍患者的急性期和长期结局，但运动疗法改善双相情感障碍病程的具体机制仍有待阐明。我们提出，运动可能通过增加神经发生和减少压力负荷来改善情绪和功能。我们回顾了一些数据，表明运动可以增加脑源性神经营养因子水平，从而增加神经发生并减少压力负荷。运动作为双相情感障碍的一种心理社会辅助疗法，应该通过严格的随机临床试验进行评估。
