婴儿多种镇静剂药物治疗戒断：右美托咪定是原因还是治疗方法？
Withdrawal from multiple sedative agent therapy in an infant: is dexmedetomidine the cause or the cure?
机构信息
University of Texas Southwestern Medical Center, Children's Medical Center, Dallas, TX, USA.
出版信息
Pediatr Crit Care Med. 2010 Jan;11(1):e1-3. doi: 10.1097/PCC.0b013e3181a66131.
OBJECTIVE
To report withdrawal symptoms experienced by an infant following the prolonged use of dexmedetomidine.
DESIGN
Case report.
SETTING
Pediatric intensive care unit at a freestanding tertiary care children's hospital.
PATIENTS
One pediatric patient with respiratory failure following pertussis infection that required prolonged intubation and sedation. The patient required dexmedetomidine to maintain optimal sedation before ventilator weaning. Subsequent to receiving dexmedetomidine the patient developed withdrawal symptoms.
CONCLUSION
In patients who fail to achieve adequate sedation with the use of traditional medications, dexmedetomidine is an adequate alternative. However, abrupt discontinuation of dexmedetomidine may result in withdrawal symptoms that may be avoided with a dexmedetomidine taper.
目的
报告一名婴儿在长期使用右美托咪定后出现的戒断症状。
设计
病例报告。
地点
一家独立的三级儿童保健医院的儿科重症监护病房。
患者
一名患有百日咳感染导致呼吸衰竭的儿科患者，需要长时间插管和镇静。患者在呼吸机脱机前需要右美托咪定来维持最佳镇静。在接受右美托咪定后，患者出现了戒断症状。
结论
对于那些使用传统药物无法达到足够镇静的患者，右美托咪定是一种合适的替代药物。然而，突然停用右美托咪定可能会导致戒断症状，而逐渐减少右美托咪定的剂量可以避免这些症状。
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