Division of Nephrology, Department of Internal Medicine, Iran University of Medical Sciences, Hasheminejad Kidney Center, Vanak square, 19697, Tehran, Iran.
Int Urol Nephrol. 2010 Dec;42(4):1031-40. doi: 10.1007/s11255-009-9684-0. Epub 2010 Jan 6.
Several registries and single centers have reported the results of their renal biopsies from different parts of the world. As there are only few data regarding the epidemiology of glomerulonephritides in Iran, this study was conducted to determine the results of renal biopsy findings during the last 10 years in our center.
Data from 1,436 patients who had undergone a renal biopsy in our center between 1998 and 2007 were collected retrospectively for the first 989 patients and prospectively for the rest of them, including demographic data, renal syndrome at presentation and laboratory findings. All kidney specimens were studied with light and immunofluorescent microscopies.
Among 1,407 patients with a definite pathologic diagnosis, 1,052 (74.8%) had a primary glomerular disease, 241 (17.2%) had a secondary glomerular disease, 66 (4.6%) had tubular disease, 19 (1.3%) had vascular disease and 7 (0.5%) had end-stage kidney disease. The most frequent types of biopsy-proven renal diseases were membranous glomerulopathy (MG) (377 patients, 26.8%), IgA nephropathy (IgAN) (155 patients, 11%), lupus nephritis (155 patients, 11%), focal segmental glomerulosclerosis (141 patients, 10%) and minimal change disease (117 patients, 8.3%). The predominant presentation was nephrotic syndrome in almost all cases, with the exception of chronic glomerulonephritis, acute tubular necrosis and acute tubulointerstitial nephritis. The epidemiology of our renal biopsy findings was similar to reports from most European countries and United Arab Emirates, but different from many other neighboring countries, North America and Far East.
In our report of 1,407 renal biopsy specimens, MG and IgAN were the most frequent biopsy-proven renal diseases. FSGS was the third cause of primary glomerular disease, and lupus nephritis was the most common secondary glomerular disease. The unusually high frequency of presentation as nephrotic syndrome may be due to referral nature of our center and less liberal indications for renal biopsy.
多个注册中心和单中心已经报道了来自世界不同地区的肾活检结果。由于伊朗关于肾小球肾炎的流行病学数据很少，因此本研究旨在确定我们中心过去 10 年的肾活检结果。
我们回顾性地收集了 1998 年至 2007 年期间在我们中心进行肾活检的 1436 名患者的数据，其中 989 名患者为前瞻性收集，其余患者为回顾性收集，包括人口统计学数据、就诊时的肾综合征和实验室发现。所有肾脏标本均行光镜和免疫荧光显微镜检查。
在 1407 名具有明确病理诊断的患者中，1052 名（74.8%）患有原发性肾小球疾病，241 名（17.2%）患有继发性肾小球疾病，66 名（4.6%）患有肾小管疾病，19 名（1.3%）患有血管疾病，7 名（0.5%）患有终末期肾病。经活检证实的最常见的肾脏疾病类型是膜性肾小球病（MG）（377 例，26.8%）、IgA 肾病（IgAN）（155 例，11%）、狼疮性肾炎（155 例，11%）、局灶节段性肾小球硬化症（141 例，10%）和微小病变性肾病（117 例，8.3%）。几乎所有病例的主要表现均为肾病综合征，除慢性肾小球肾炎、急性肾小管坏死和急性肾小管间质性肾炎外。我们的肾活检结果的流行病学与大多数欧洲国家和阿拉伯联合酋长国的报告相似，但与许多其他邻国、北美和远东地区不同。
在我们的 1407 例肾活检标本报告中，MG 和 IgAN 是最常见的经活检证实的肾脏疾病。FSGS 是原发性肾小球疾病的第三大病因，狼疮性肾炎是最常见的继发性肾小球疾病。肾病综合征如此高的发病率可能是由于我们中心的转诊性质和对肾活检的指征不够宽松。
